Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/8347
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dc.contributor.authorLushington, K.en
dc.contributor.authorDawson, D.en
dc.contributor.authorKennaway, D.en
dc.contributor.authorLack, L.en
dc.date.issued1999en
dc.identifier.citationJournal of Sleep Research, 1999; 8(1):57-64en
dc.identifier.issn0962-1105en
dc.identifier.issn1365-2869en
dc.identifier.urihttp://hdl.handle.net/2440/8347-
dc.description.abstractThe pineal hormone, melatonin, is reported to possess hypnotic properties. This has led to an investigation of the relationship between the endogenous melatonin rhythm and sleep. However, this relationship has yet to be fully examined in aged insomniacs and controls. From media advertisements, 16 good sleeping controls (11F, 5M) and 16 sleep maintenance insomniacs (11F, 5M), aged over 55 years, were recruited to participate in a study involving four nights of polysomnographically (PSG) measured sleep followed by a 26 h constant routine. During the constant routine, 2 h urine samples were collected and analysed for the melatonin metabolite, 6-sulphatoxymelatonin (aMT.6S). This was used to determine total melatonin excretion. As well, the following circadian melatonin parameters were calculated from fifth order polynomial curve fitting analyses, the goodness of the polynomial curve fit, peak melatonin concentration, the phase of the melatonin rhythm, and melatonin and sleep rhythm synchrony. Apart for one control, all subjects showed significant circadian melatonin rhythms. Although insomniacs showed a greater amount of wakefulness, less sleep in total, and lower sleep efficiency, no significant group differences were observed in any of the melatonin parameters. In addition, while subjects with more reliable melatonin curve fits showed shorter sleep latencies and higher sleep efficiencies, correlational analyses revealed no other significant relationships between any melatonin and PSG sleep parameters. Overall, the present results suggest that neither melatonin amplitude nor phase are related to sleep quality in the aged.en
dc.language.isoenen
dc.publisherBLACKWELL SCIENCE LTDen
dc.subjectHumans; Melatonin; Electroencephalography; Electrooculography; Polysomnography; Wakefulness; Sleep, REM; Circadian Rhythm; Time Factors; Aged; Aged, 80 and over; Middle Aged; Female; Maleen
dc.titleThe relationship between 6-sulphatoxymelatonin and polysomnographic sleep in good sleeping controls and wake maintenance insomniacs, aged 55-80 yearsen
dc.typeJournal articleen
dc.identifier.rmid0030005224en
dc.identifier.doi10.1046/j.1365-2869.1999.00130.xen
dc.identifier.pubid69230-
pubs.library.collectionObstetrics and Gynaecology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidKennaway, D. [0000-0002-5864-3514]en
Appears in Collections:Obstetrics and Gynaecology publications

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