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https://hdl.handle.net/2440/84421
Type: | Book chapter |
Title: | Biobanks and biobank harmonisation |
Author: | Burton, P. Fortier, I. Deschenes, M. Hansell, A. Palmer, L. |
Citation: | An Introduction to Genetic Epidemiology, 2011 / Palmer, L., Smith, G., Burton, P. (ed./s), pp.155-174 |
Publisher: | The Policy Press |
Publisher Place: | Bristol, UK |
Issue Date: | 2011 |
ISBN: | 9781861348975 |
Editor: | Palmer, L. Smith, G. Burton, P. |
Statement of Responsibility: | Paul R. Burton, Isabel Fortier, Mylene DeschĂȘnes, Anna Hansell, Lyle J. Palmer |
Abstract: | Over the past decade and a half, genetic epidemiology has experienced an important shift from family-based studies of genetic linkage to individual-based studies of genetic association (Chapters One-Four). In part, this follows the recognition that if the 'common disease, common variant hypothesis'1-5 is true for at least a proportion of important genetic determinants of complex disease, these determinants - which will predominantly exhibit weak aetiological effects6 - will be identified more easily using association studies of population-based samples7. The shift to using association studies has been accompanied by an increasing methodological focus on optimal approaches to the design, analysis, meta-analysis and reporting of genetic association studies8-15; 65-67 (www.cdc.gov/genomics/ hugenet/strega.htm). This chapter describes these changes, and the growing international focus on biobanks with which they are associated. |
Appears in Collections: | Aurora harvest Translational Health Science publications |
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