Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/8453
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorRoberts, C.en
dc.contributor.authorSohlstrom, A.en
dc.contributor.authorKind, K.en
dc.contributor.authorGrant, P.en
dc.contributor.authorEarl, R.en
dc.contributor.authorRobinson, J.en
dc.contributor.authorKhong, T.en
dc.contributor.authorOwens, P.en
dc.contributor.authorOwens, J.en
dc.date.issued2001en
dc.identifier.citationPlacenta, 2001; 22(Suppl A):S77-S82en
dc.identifier.issn0143-4004en
dc.identifier.issn1532-3102en
dc.identifier.urihttp://hdl.handle.net/2440/8453-
dc.description.abstractMaternal feed restriction may restrict fetal growth in part indirectly by impairing placental functional development. Such actions could be mediated by the insulin-like growth factors (IGF), which are important modulators of placental growth and differentiation and more generally, are influenced by nutrient availability. While a role for the fetal IGF axis has been demonstrated, less is known of the influence, if any, of that in the mother. This study aimed to determine whether alterations in the maternal IGF axis and placental functional and structural development due to maternal food restriction are related. We therefore examined the associations between placental structural parameters, the ratios of maternal to fetal plasma glucose and fetal to maternal plasma urea concentration, and maternal circulating IGF-I, IGF-II and IGFBP-2 in ad libitum fed and food restricted (70–90 per cent of the ad libitum intake) pregnant guinea pigs. In mid-gestation, fetal weight (r=0.65, P=0.008, n=17), volume of the maternal blood space (r=0.58, P=0.048, n=17), and surface density of syncytiotrophoblast (r=0.65, P=0.023, n=17), were positively correlated, and syncytiotrophoblast thickness was negatively correlated, with maternal plasma IGF-II concentration (r=−0.69,P =0.014, n=17). Late in gestation, fetal weight, placental weight and total exchange surface area in the placenta were each negatively correlated with maternal plasma IGFBP-2 concentration (all P< 0.01), while the arithmetic mean thickness of syncytiotrophoblast was positively correlated with maternal plasma IGFBP-2 concentration. Late in gestation, the ratio of maternal to fetal plasma glucose was positively correlated with fetal weight (r=0.54,P =0.038, n=15) and the ratio of fetal to maternal plasma urea concentration was positively correlated with placental weight (r=0.52, P=0.046, n=15). Maternal feed restriction reduced the ratio of maternal plasma IGF-II to IGFBP-2 in late gestation by 75 per cent (P=0.001) and this ratio was positively correlated with fetal weight (r=0.56, P=0.01, n=20), placental weight (r=0.59, P=0.006), placental diameter (r=0.621, P=0.003), placental volume (r=0.57, P=0.009), weight of trophoblast (r=0.51,P =0.037), weight of fetal capillaries (r=0.49, P=0.046), syncytiotrophoblast surface density (r=0.611, P=0.009) and negatively correlated with syncytiotrophoblast thickness (r=−0.55, P=0.021). Our results suggest that in mid-pregnancy, maternal circulating IGF-II promotes placental structural development, while later in pregnancy, IGFBP-2 inhibits it, and their relative abundance and interaction strongly influences placental structure and function near term.en
dc.description.statementofresponsibilityC. T. Roberts, A. Sohlstrom, K. L. Kind, P. A. Grant, R. A. Earl, J. S. Robinson, T. Y. Khong, P. C. Owens and J. A. Owensen
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/623064/description#descriptionen
dc.language.isoenen
dc.publisherW B Saunders Co Ltden
dc.subjectTrophoblasts; Placenta; Animals; Guinea Pigs; Fetal Weight; Urea; Blood Glucose; Insulin-Like Growth Factor II; Insulin-Like Growth Factor Binding Protein 2; Organ Size; Food Deprivation; Gestational Age; Pregnancy; Maternal-Fetal Exchange; Blood Volume; Femaleen
dc.titleAltered placental structure induced by maternal food restriction in guinea pigs: A role for circulating IGF-II and IGFBP-2 in the mother?en
dc.typeJournal articleen
dc.identifier.rmid0020010861en
dc.identifier.doi10.1053/plac.2001.0643en
dc.identifier.pubid61743-
pubs.library.collectionObstetrics and Gynaecology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidRoberts, C. [0000-0002-9250-2192]en
dc.identifier.orcidRobinson, J. [0000-0002-4515-6039]en
dc.identifier.orcidKhong, T. [0000-0002-2404-007X]en
dc.identifier.orcidOwens, J. [0000-0002-7498-1353]en
Appears in Collections:Physiology publications
Obstetrics and Gynaecology publications
Agriculture, Food and Wine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.