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Type: Journal article
Title: Fetal fibronectin as a predictor of spontaneous preterm birth: A European perspective
Author: Chandiramani, M.
Di Renzo, G.
Gottschalk, E.
Helmer, H.
Henrich, W.
Hoesli, I.
Mol, B.
Norman, J.
Robson, S.
Thornton, S.
Shennan, A.
Citation: The Journal of Maternal - Fetal & Neonatal Medicine, 2011; 24(2):330-336
Publisher: Informa Healthcare
Issue Date: 2011
ISSN: 1476-7058
Statement of
Manju Chandiramani, Gian C. Di Renzo, Elisabeth Gottschalk, Hanns Helmer, Wolfgang Henrich, Irene Hoesli, Ben Mol, Jane E. Norman, Stephen Robson, Steven Thornton, & Andrew Shennan
Abstract: Preterm birth (PTB) is estimated to account for 6-10% of all births worldwide with 13 million PTBs occurring annually and 1 million resulting in death. The diagnosis of spontaneous preterm labor and accurate prediction of preterm delivery is notoriously difficult. Identification of effective risk assessment markers can potentially improve outcomes by enabling targeted therapy while allowing efficient use of resources and avoiding unnecessary interventions. Advances in perinatal medicine have not reduced PTB and effective measures that improve outcome are yet to be established. However, considerable progress has been made in the development of accurate methods (fetal fibronectin and cervical length assessment) to predict PTB in both symptomatic and asymptomatic high-risk women. The excellent negative predictive value of fFN has the ability to facilitate decision-making regarding admission, in utero transfer, administration of antenatal corticosteroids and/or tocolysis and has been shown to be cost-effective. This review describes the European perspective on the use of fFN and describes ongoing European clinical studies, which are appropriately designed with meaningful endpoints, which will undoubtedly facilitate a better understanding of test accuracy and cost-effectiveness within different populations.
Keywords: Fetal fibronectin; spontaneous preterm birth; prediction; cost-effectiveness
Rights: © 2011 Informa UK, Ltd.
RMID: 0020136775
DOI: 10.3109/14767058.2010.496879
Appears in Collections:Obstetrics and Gynaecology publications

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