Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/84934
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Type: Journal article
Title: Hospitalisation with infection, asthma and allergy in Kawasaki disease patients and their families: Genealogical analysis using linked population data
Author: Webster, R.
Carter, K.
Warrington, N.
Loh, A.
Zaloumis, S.
Kuijpers, T.
Palmer, L.
Burgner, D.
Citation: PLoS One, 2011; 6(11):e28004-1-e28004-7
Publisher: Public Library of Science
Issue Date: 2011
ISSN: 1932-6203
1932-6203
Statement of
Responsibility: 
Rebecca J. Webster, Kim W. Carter, Nicole M. Warrington, Angeline M. Loh, Sophie Zaloumis, Taco W. Kuijpers, Lyle J. Palmer, David P. Burgner
Abstract: Background: Kawasaki disease results from an abnormal immunological response to one or more infectious triggers. We hypothesised that heritable differences in immune responses in Kawasaki disease-affected children and their families would result in different epidemiological patterns of other immune-related conditions. We investigated whether hospitalisation for infection and asthma/allergy were different in Kawasaki disease-affected children and their relatives. Methods/Major Findings: We used Western Australian population-linked health data from live births (1970–2006) to compare patterns of hospital admissions in Kawasaki disease cases, age- and sex-matched controls, and their relatives. There were 295 Kawasaki disease cases and 598 age- and sex-matched controls, with 1,636 and 3,780 relatives, respectively. Compared to controls, cases were more likely to have been admitted at least once with an infection (cases, 150 admissions (50.8%) vs controls, 210 admissions (35.1%); odds ratio (OR) = 1.9, 95% confidence interval (CI) 1.4–2.6, P = 7.2×10−6), and with asthma/allergy (cases, 49 admissions (16.6%) vs controls, 42 admissions (7.0%); OR = 2.6, 95% CI 1.7–4.2, P = 1.3×10−5). Cases also had more admissions per person with infection (cases, median 2 admissions, 95% CI 1–5, vs controls, median 1 admission, 95% CI 1–4, P = 1.09×10−5). The risk of admission with infection was higher in the first degree relatives of Kawasaki disease cases compared to those of controls, but the differences were not significant. Conclusion: Differences in the immune phenotype of children who develop Kawasaki disease may influence the severity of other immune-related conditions, with some similar patterns observed in relatives. These data suggest the influence of shared heritable factors in these families.
Keywords: Humans; Communicable Diseases; Asthma; Mucocutaneous Lymph Node Syndrome; Hospitalization; Incidence; Linear Models; Case-Control Studies; Family; Public Health; Age of Onset; Age Distribution; Genealogy and Heraldry; Adolescent; Adult; Child; Child, Preschool; Infant; Infant, Newborn; Western Australia; Female; Male; Databases as Topic; Young Adult
Rights: © 2011 Webster et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
RMID: 0020136617
DOI: 10.1371/journal.pone.0028004
Appears in Collections:Translational Health Science publications

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