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Type: Journal article
Title: Using the zebrafish model for Alzheimer's disease research
Author: Newman, M.
Ebrahimie, E.
Lardelli, M.
Citation: Frontiers in Genetics, 2014; 5(JUN):189-1-189-10
Publisher: Frontiers Research Foundation
Issue Date: 2014
ISSN: 1664-8021
Statement of
Morgan Newman, Esmaeil Ebrahimie and Michael Lardelli
Abstract: Rodent models have been extensively used to investigate the cause and mechanisms behind Alzheimer's disease. Despite many years of intensive research using these models we still lack a detailed understanding of the molecular events that lead to neurodegeneration. Although zebrafish lack the complexity of advanced cognitive behaviors evident in rodent models they have proven to be a very informative model for the study of human diseases. In this review we give an overview of how the zebrafish has been used to study Alzheimer's disease. Zebrafish possess genes orthologous to those mutated in familial Alzheimer's disease and research using zebrafish has revealed unique characteristics of these genes that have been difficult to observe in rodent models. The zebrafish is becoming an increasingly popular model for the investigation of Alzheimer's disease and will complement studies using other models to help complete our understanding of this disease.
Keywords: zebrafish; Alzheimer disease; presenilins; gamma-secretase; amyloid beta-protein precursor; MAPT
Rights: © 2014 Newman, Ebrahimie and Lardelli. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
RMID: 0030008002
DOI: 10.3389/fgene.2014.00189
Appears in Collections:Genetics publications

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