Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/85497
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dc.contributor.authorNewman, M.en
dc.contributor.authorEbrahimie, E.en
dc.contributor.authorLardelli, M.en
dc.date.issued2014en
dc.identifier.citationFrontiers in Genetics, 2014; 5(JUN):189-1-189-10en
dc.identifier.issn1664-8021en
dc.identifier.issn1664-8021en
dc.identifier.urihttp://hdl.handle.net/2440/85497-
dc.description.abstractRodent models have been extensively used to investigate the cause and mechanisms behind Alzheimer's disease. Despite many years of intensive research using these models we still lack a detailed understanding of the molecular events that lead to neurodegeneration. Although zebrafish lack the complexity of advanced cognitive behaviors evident in rodent models they have proven to be a very informative model for the study of human diseases. In this review we give an overview of how the zebrafish has been used to study Alzheimer's disease. Zebrafish possess genes orthologous to those mutated in familial Alzheimer's disease and research using zebrafish has revealed unique characteristics of these genes that have been difficult to observe in rodent models. The zebrafish is becoming an increasingly popular model for the investigation of Alzheimer's disease and will complement studies using other models to help complete our understanding of this disease.en
dc.description.statementofresponsibilityMorgan Newman, Esmaeil Ebrahimie and Michael Lardellien
dc.language.isoenen
dc.publisherFrontiers Research Foundationen
dc.rights© 2014 Newman, Ebrahimie and Lardelli. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.subjectzebrafish; Alzheimer disease; presenilins; gamma-secretase; amyloid beta-protein precursor; MAPTen
dc.titleUsing the zebrafish model for Alzheimer's disease researchen
dc.typeJournal articleen
dc.identifier.rmid0030008002en
dc.identifier.doi10.3389/fgene.2014.00189en
dc.identifier.pubid75543-
pubs.library.collectionGenetics publicationsen
pubs.library.teamDS02en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidNewman, M. [0000-0002-4930-4529]en
dc.identifier.orcidEbrahimie, E. [0000-0002-4431-2861]en
dc.identifier.orcidLardelli, M. [0000-0002-4289-444X]en
Appears in Collections:Genetics publications

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