Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/85704
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Type: Journal article
Title: A comparison of radiostereometric analysis and computed tomography for the assessment of lumbar spinal fusion in a sheep model
Author: Humadi, A.
Freeman, B.
Moore, R.
Callary, S.
Halldin, K.
David, V.
Maclaurin, W.
Tauro, P.
Scoenwaelder, M.
Citation: Evidence-Based Spine-Care Journal, 2013; 4(2):78-89
Publisher: Thieme Medical Publishers
Issue Date: 2013
ISSN: 1663-7976
1869-4136
Statement of
Responsibility: 
Ali Humadi, Brian J. C. Freeman, Rob J. Moore, Stuart Callary, Klas Halldin, Vikram David, William Maclaurin, Paul Tauro, Mark Schoenwaelder
Abstract: Objective: The aim of this animal study is to evaluate the accuracy of radiostereometric analysis (RSA) compared with computed tomographic (CT) scan in the assessment of spinal fusion after anterior lumbar interbody fusion (ALIF) using histology as a gold standard. Methods: Three non-adjacent ALIFs (L1–L2, L3–L4, and L5–L6) were performed in nine sheep. The sheep were divided into three groups of three sheep. All the animals were humanely killed immediately after having the last scheduled RSA. The lumbar spine was removed and in vitro fine cut CT and histopathology were performed. Results: Using histological assessment as the gold standard for assessing fusion, RSA demonstrated better results (100% sensitivity and 66.7% specificity; positive predictive value [PPV] = 27.3%, negative predictive value [NPV] =100.0%) compared with CT (66.7% sensitivity and 60.0% specificity [PPV = 16.7%, NPV = 93.8%]). Conclusions: RSA demonstrated higher sensitivity and specificity when compared with CT. Furthermore, RSA has the advantage of much lower radiation exposure compared with fine cut CT. Further studies are required to see if RSA remains superior to CT scan for the assessment spinal fusion in the clinical setting.
Keywords: radiostereometric analysis; spinal fusion; assessment; computed tomography; histology
Rights: © 2013, Rights Managed by Georg Thieme Verlag KG Stuttgart
RMID: 0020137117
DOI: 10.1055/s-0033-1357359
Appears in Collections:Orthopaedics and Trauma publications

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