Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/8574
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Type: Journal article
Title: Criteria for the objective definition of transient lower esophageal sphincter relaxation
Author: Holloway, R.
Penagini, R.
Ireland, A.
Citation: American Journal of Physiology, 1995; 268(1):G128-G133
Publisher: American Physiological Society
Issue Date: 1995
ISSN: 0002-9513
2163-5773
Statement of
Responsibility: 
Richard H. Holloway, Roberto Penagini, and Alan C. Ireland
Abstract: We developed and evaluated objective manometric criteria that define transient lower esophageal sphincter (LES) relaxation. In 23 normal subjects and 9 patients with gastroesophageal reflux disease, systematic analysis of swallow-induced LES relaxation showed that dry swallows preceded LES relaxation by a median of 1.4 s. The relaxation rate was always > 1 mmHg/s, the relaxation nadir always occurred within 7 s, and the duration of relaxation was < 9 s. During concurrent esophageal manometry and pH monitoring, 104 reflux episodes associated with a LES pressure fall that was not related to swallowing were identified and the pressure falls classified as transient LES relaxations or not by visual recognition. LES pressure was always < or = 2 mmHg at time of reflux, and relaxation was significantly longer than for swallow-induced LES relaxation. Of 88 pressure falls classified visually as transient LES relaxations, 90% reached nadir pressure within 7 s at a rate of > 1 mmHg/s. Sixteen pressure falls were classified as a gradual downward drift in LES pressure, which in 15 cases was < 1 mmHg/s. Based on the analysis, transient LES relaxation can be defined by 1) absence of swallowing for 4 s before to 2 s after the onset of LES relaxation, 2) relaxation rate of > or = 1 mmHg/s, 3) time from onset to complete relaxation of < or = 10 s, and 4) nadir pressure of < or = 2 mmHg.(ABSTRACT TRUNCATED AT 250 WORDS)
Keywords: Esophagogastric Junction; Humans; Gastroesophageal Reflux; Deglutition; Muscle Relaxation; Pressure; Time Factors; Adolescent; Adult; Middle Aged; Female; Male; Terminology as Topic
Rights: Copyright © 1995 the American Physiological Society
RMID: 0030005134
DOI: 10.1152/ajpgi.1995.268.1.g128
Published version: http://ajpgi.physiology.org/content/268/1/G128
Appears in Collections:Medicine publications

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