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https://hdl.handle.net/2440/8581
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dc.contributor.author | Sun, W.M. | - |
dc.contributor.author | Doran, S. | - |
dc.contributor.author | Jones, K. | - |
dc.contributor.author | Ooi, E. | - |
dc.contributor.author | Boeckxstaens, G. | - |
dc.contributor.author | Hebbard, G. | - |
dc.contributor.author | Lingenfelser, T. | - |
dc.contributor.author | Morley, J. | - |
dc.contributor.author | Dent, J. | - |
dc.contributor.author | Horowitz, M. | - |
dc.date.issued | 1998 | - |
dc.identifier.citation | American Journal of Physiology: Gastrointestinal and Liver Physiology, 1998; 275(5):G1173-G1178 | - |
dc.identifier.issn | 1522-1547 | - |
dc.identifier.issn | 1522-1547 | - |
dc.identifier.uri | http://hdl.handle.net/2440/8581 | - |
dc.description.abstract | The effects of the nitric oxide donor nitroglycerin on gastric emptying and antropyloroduodenal motility were evaluated in nine healthy male subjects (ages 19-36 yr). Antropyloroduodenal pressures were recorded with a manometric assembly that had nine side holes spanning the antrum and proximal duodenum and a pyloric sleeve sensor; gastric emptying was quantified scintigraphically. In each subject, the emptying of 300 ml of 25% glucose labeled with 99mTc was assessed on two separate days during intravenous infusion of either nitroglycerin (5 micrograms/min in 5% dextrose) or 5% dextrose (control). Studies were performed with the subject in the supine position; blood pressure and heart rate were monitored. Nitroglycerin had no significant effect on blood pressure or heart rate. Nitroglycerin slowed gastric emptying (P < 0.02), and this was associated with greater retention of the drink in the proximal stomach (P < 0.05). In both nitroglycerin and control studies, ingestion of the drink was associated with an increase in the number of isolated pyloric pressure waves (P < 0.05) and antral pressure wave sequences (P < 0.05). Nitroglycerin reduced the number of isolated pyloric pressure waves (P < 0.05), basal pyloric pressure (P < 0.05), and the number of antral pressure wave sequences (P < 0. 05), but not the total number of antral pressure waves. The rate of gastric emptying and the number of isolated pyloric pressure waves were inversely related during control (P = 0.03) and nitroglycerin (P < 0.05) infusions. We conclude that in normal subjects, 1) gastric emptying of 300 ml of 25% glucose is inversely related to the frequency of phasic pyloric pressure waves, and 2) nitroglycerin in a dose of 5 micrograms/min inhibits pyloric motility, alters the organization but not the number of antral pressure waves, and slows gastric emptying and intragastric distribution of 25% glucose. | - |
dc.description.statementofresponsibility | W.-M. Sun, S. Doran, K. L. Jones, E. Ooi, G. Boeckxstaens, G. S. Hebbard, T. Lingenfelser, J. E. Morley, J. Dent, M. Horowit | - |
dc.language.iso | en | - |
dc.publisher | American Physiological Society | - |
dc.rights | © 1998, The American Physiological Society | - |
dc.source.uri | http://ajpgi.physiology.org/content/275/5/G1173 | - |
dc.subject | Antrum pyloricum | - |
dc.subject | Duodenum | - |
dc.subject | Gastric emptying | - |
dc.subject | Nitric oxide | - |
dc.subject | Nutrition | - |
dc.subject | Nitroglycerin | - |
dc.subject | Organic nitrate | - |
dc.subject | Human | - |
dc.subject | Motility | - |
dc.subject | Stomach | - |
dc.subject | Digestive system | - |
dc.subject | Small intestine | - |
dc.title | Effects of nitroglycerin on liquid gastric emptying and antropyloroduodenal motility | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1152/ajpgi.1998.275.5.g1173 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Jones, K. [0000-0002-1155-5816] | - |
dc.identifier.orcid | Morley, J. [0000-0001-6444-2965] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
Appears in Collections: | Aurora harvest Medicine publications |
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