Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/85959
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dc.contributor.author | Shi, B. | - |
dc.contributor.author | Zhang, H. | - |
dc.contributor.author | Dai, S. | - |
dc.contributor.author | Du, X. | - |
dc.contributor.author | Bi, J. | - |
dc.contributor.author | Qiao, S. | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Small, 2014; 10(5):871-877 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.issn | 1613-6829 | - |
dc.identifier.uri | http://hdl.handle.net/2440/85959 | - |
dc.description.abstract | A new strategy for promoting endoplasmic gene delivery and nucleus uptake is proposed by developing intracellular microenvironment responsive biocompatible polymers. This delivery system can efficiently load and self-assemble nucleic acids into nano-structured polyplexes at a neutral pH, release smaller imidazole-gene complexes from the polymer backbones at intracellular endosomal pH, transport nucleic acids into nucleus through intracellular environment responsive multiple-stage gene delivery, thus leading to a high cell transfection efficiency. | - |
dc.description.statementofresponsibility | Bingyang Shi, Hu Zhang, Sheng Dai, Xin Du, Jingxiu Bi and Shi Zhang Qiao | - |
dc.language.iso | en | - |
dc.publisher | Wiley - VCH Verlag GmbH & Co KGaA | - |
dc.rights | © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | - |
dc.source.uri | http://dx.doi.org/10.1002/smll.201302430 | - |
dc.subject | Hela Cells | - |
dc.subject | Humans | - |
dc.subject | Schiff Bases | - |
dc.subject | Imidazoles | - |
dc.subject | Polymers | - |
dc.subject | Chitosan | - |
dc.subject | DNA | - |
dc.subject | Gene Transfer Techniques | - |
dc.subject | Transfection | - |
dc.subject | Plasmids | - |
dc.subject | Particle Size | - |
dc.subject | Cellular Microenvironment | - |
dc.title | Intracellular microenvironment responsive polymers: a multiple-stage transport platform for high-performance gene delivery | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1002/smll.201302430 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DP130104459 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DP110102877 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Zhang, H. [0000-0003-4178-6401] | - |
dc.identifier.orcid | Bi, J. [0000-0001-7056-8572] | - |
dc.identifier.orcid | Qiao, S. [0000-0002-1220-1761] [0000-0002-4568-8422] | - |
Appears in Collections: | Aurora harvest 7 Chemical Engineering publications |
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