Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/8621
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Brown, M. | - |
dc.contributor.author | Kennedy, L. | - |
dc.contributor.author | Darke, C. | - |
dc.contributor.author | Gibson, K. | - |
dc.contributor.author | Pile, K. | - |
dc.contributor.author | Shatford, J. | - |
dc.contributor.author | Taylor, A. | - |
dc.contributor.author | Calin, A. | - |
dc.contributor.author | Wordsworth, B. | - |
dc.date.issued | 1998 | - |
dc.identifier.citation | Arthritis and Rheumatism, 1998; 41(3):460-465 | - |
dc.identifier.issn | 0004-3591 | - |
dc.identifier.uri | http://hdl.handle.net/2440/8621 | - |
dc.description | Article first published online: 28 MAY 2004 | - |
dc.description.abstract | Objective: To analyze the effect of HLA-DR genes on susceptibility to and severity of ankylosing spondylitis (AS). Methods: Three hundred sixty-three white British AS patients were studied; 149 were carefully assessed for a range of clinical manifestations, and disease severity was assessed using a structured questionnaire. Limited HLA class I typing and complete HLA-DR typing were performed using DNA-based methods. HLA data from 13,634 healthy white British bone marrow donors were used for comparison. Results: A significant association between DR1 and AS was found, independent of HLA-B27 (overall odds ratio [OR] 1.4, 95% confidence interval [95% CI] 1.1-1.8, P = 0.02; relative risk [RR] 2.7, 95% CI 1.5-4.8, P = 6 × 10-4 among homozygotes; RR 2.1, 95% CI 1.5-2.8, P = 5 × 10-6 among heterozygotes). A large but weakly significant association between DR8 and AS was noted, particularly among DR8 homozygotes (RR 6.8, 95% CI 1.6-29.2, P = 0.01 among homozygotes; RR 1.6, 95% CI 1.0-2.7, P = 0.07 among heterozygotes). A negative association with DR12 (OR 0.22, 95% CI 0.09-0.5, P = 0.001) was noted. HLA-DR7 was associated with younger age at onset of disease (mean age at onset 18 years for DR7-positive patients and 23 years for DR7-negative patients; Z score 3.21, P = 0.001). No other HLA class I or class II associations with disease severity or with different clinical manifestations of AS were found. Conclusion: The results of this study suggest that HLA-DR genes may have a weak effect on susceptibility to AS independent of HLA-B27, but do not support suggestions that they affect disease severity or different clinical manifestations. | - |
dc.description.statementofresponsibility | Matthew A. Brown, L. Gail Kennedy, Chris Darke, Kathryn Gibson, Kevin D. Pile, Jane L. Shatford, Andrew Taylor, Andrei Calin, B. Paul Wordsworth | - |
dc.language.iso | en | - |
dc.publisher | Wiley | - |
dc.rights | © 1998, American College of Rheumatology | - |
dc.source.uri | http://onlinelibrary.wiley.com/doi/10.1002/1529-0131(199803)41:3%3C460::AID-ART12%3E3.0.CO;2-X/abstract | - |
dc.title | The effect of HLA-DR genes on susceptibility to and severity of ankylosing spondylitis | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1002/1529-0131(199803)41:3<460::AID-ART12>3.0.CO;2-X | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 4 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.