Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/86288
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: 15-lipoxygenase gene variants are associated with carotid plaque but not carotid intima-media thickness
Author: McCaskie, P.
Beilby, J.
Hung, J.
Chapman, C.
McQuillan, B.
Powell, B.
Thompson, P.
Palmer, L.
Citation: Human Genetics, 2008; 123(5):445-453
Publisher: Springer-Verlag
Issue Date: 2008
ISSN: 0340-6717
1432-1203
Statement of
Responsibility: 
Pamela A. McCaskie, John P. Beilby, Joseph Hung, Caroline M. L. Chapman, Brendan M. McQuillan, Brenda L. Powell, Peter L. Thompson, Lyle J. Palmer
Abstract: The major underlying cause of CHD is atherosclerosis, and oxidised LDL is known to play an important role in its development. We examined the role of three single nucleotide polymorphisms (SNPs) in the 15-lipoxygenase gene (ALOX15), in atherosclerosis. We genotyped three SNPs in the ALOX15 promoter in two Western Australian samples—1,111 community-based individuals and 556 with CHD. SNPs and haplotypes were tested for an association with carotid plaque, intima-media thickness and risk of CHD. The −611GG genotype was associated with increased likelihood of carotid plaque in CHD patients (OR = 4.01, 95%CI = 1.39–11.53, P = 0.005) and the C alleles of the G-220C and G-189C SNPs were associated with decreased likelihood of plaque among cases (OR = 0.66, 95%CI = 0.43–0.99, P = 0.05 and OR = 0.51, 95%CI = 0.34–0.78, P = 0.002 respectively). The GGG haplotype was associated with increased risk of carotid plaque in CHD patients (OR = 5.77, 95%CI = 1.82–18.29, P = 0.0007) and in community-based individuals under 53 years (OR = 4.15, 95%CI = 1.23–14.08, P = 0.02). No association was observed between ALOX15 SNPs or haplotypes and intima-media thickness. This study is novel as it is the first to examine the association between 15-lipoxygenase polymorphisms and atherosclerotic indicators. These findings suggest a possible role of ALOX15 polymorphisms in focal plaque formation.
Keywords: Carotid Arteries; Tunica Intima; Humans; Carotid Artery Diseases; Arachidonate 15-Lipoxygenase; Case-Control Studies; Cross-Sectional Studies; Haplotypes; Adult; Aged; Middle Aged; Female; Male; Atherosclerosis; Genetic Variation
Rights: © Springer-Verlag 2008
RMID: 0020136662
DOI: 10.1007/s00439-008-0496-6
Appears in Collections:Translational Health Science publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.