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https://hdl.handle.net/2440/8651
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Type: | Journal article |
Title: | Clinical associations of anti-lamin autoantibodies. |
Author: | Hill, C. Roberts-Thomson, P. Pollard, A. Gillis, D. Kirkham, B. |
Citation: | Australian and New Zealand journal of medicine, 1996; 26(2):162-166 |
Publisher: | ADIS PRESS AUSTRALASIA P/L |
Issue Date: | 1996 |
ISSN: | 0004-8291 |
Abstract: | <h4>Background</h4>The clinical associations of anti-lamin autoantibodies were first described in 1973. Since then a number of individual case reports and two small series have been published. These have suggested an association with connective tissue disorders and autoimmune liver disease.<h4>Aims</h4>To identify the clinical and laboratory associations of anti-lamin autoantibodies in an Australian population.<h4>Methods</h4>Retrospective review of routine antinuclear antibody testing between 1990-1994 for characteristics linear staining of nuclear envelope on indirect immunofluorescence on HEp-2 cells with clinical status defined by retrospective review of case records.<h4>Results</h4>Twenty-eight patients were identified and the clinical status of 27 patients defined. Eleven patients had associated IgG anti-cardiolipin antibodies; anti-phospholipid syndrome was present in nine. Seven further patients had liver disease; five had autoimmune liver disease, with associated autoantibodies. The remaining nine patients had a diverse group of diseases. There was no correlation between the titre of the autoantibody and clinical status. An association with anti-cardiolipin antibodies was found although the cause remains obscure.<h4>Conclusion</h4>Anti-lamin autoantibodies, as identified by indirect immunofluorescence, are associated with a diverse group of diseases but particularly with anti-phospholipid syndrome and liver disease. Testing for anti-phospholipid antibodies and more specific markers of systemic lupus erythematosus and autoimmune disease, for example anti-dsDNA antibodies, anti-smooth muscle antibodies and anti-mitochondrial antibodies should be pursued when anti-lamin autoantibodies are detected. |
Keywords: | Humans Autoimmune Diseases Nuclear Proteins Lamins Antibodies, Antinuclear Fluorescent Antibody Technique, Indirect Retrospective Studies Adult Aged Aged, 80 and over Middle Aged Australia Female Male |
DOI: | 10.1111/j.1445-5994.1996.tb00879.x |
Published version: | http://dx.doi.org/10.1111/j.1445-5994.1996.tb00879.x |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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