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Type: Journal article
Title: Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
Author: Artigas, M.
Loth, D.
Wain, L.
Gharib, S.
Obeidat, M.
Tang, W.
Zhai, G.
Zhao, J.
Smith, A.
Huffman, J.
Albrecht, E.
Jackson, C.
Evans, D.
Cadby, G.
Fornage, M.
Manichaikul, A.
Lopez, L.
Johnson, T.
Aldrich, M.
Aspelund, T.
et al.
Citation: Nature Genetics, 2011; 43(11):1082-1090
Publisher: Nature Publishing Group
Issue Date: 2011
ISSN: 1061-4036
Statement of
María Soler Artigas ... Lyle J Palmer ... et al.
Abstract: Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10−8) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.
Keywords: International Lung Cancer Consortium; GIANT consortium; Humans; Pulmonary Disease, Chronic Obstructive; Respiratory Function Tests; Child; European Continental Ancestry Group; Genome-Wide Association Study
Rights: © 2011 Nature America Inc. All rights reserved.
RMID: 0020137837
DOI: 10.1038/ng.941
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Appears in Collections:Translational Health Science publications

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