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Type: Journal article
Title: Long-term outcomes in women with polycystic ovary syndrome initially randomized to receive laparoscopic electrocautery of the ovaries or ovulation induction with gonadotrophins
Author: Nahuis, M.
Kose, N.
Bayram, N.
van Dessel, H.
Braat, D.
Hamilton, C.
Hompes, P.
Bossuyt, P.
Mol, B.
van der Veen, F.
van Wely, M.
Citation: Human Reproduction, 2011; 26(7):1899-1904
Publisher: Oxford University Press
Issue Date: 2011
ISSN: 0268-1161
Statement of
M.J. Nahuis, N. Kose, N. Bayram, H.J.H.M. van Dessel, D.D.M. Braat, C.J.C.M. Hamilton, P.G.A. Hompes, P.M. Bossuyt, B.W.J. Mol, F. van der Veen and M. van Wely
Abstract: BACKGROUND Long-term effects of laparoscopic electrocautery of the ovaries are unknown. To study the long-term effects of laparoscopic electrocautery of the ovaries and gonadotrophins, we followed women with clomiphene-resistant polycystic ovary syndrome (PCOS) randomly allocated to one of these treatments until 8–12 years after their initial treatment. METHODS Between February 1998 and October 2001 168 women with clomiphene citrate-resistant PCOS were included in a randomized controlled trial comparing an electrocautery strategy to a strategy starting with rFSH. In 2009 these women were contacted about their reproductive outcome and menstrual cycle regularity. Analysis was by intention-to-treat. We compared time to conception resulting in live birth, subsequent pregnancies, ectopic and multiple pregnancies, menopause, as well as minimal and maximal menstrual cycle length. RESULTS After 8–12 years, the cumulative proportion of women with a first child was 86% in women who had been allocated to electrocautery versus 81% in women who had been allocated to immediate rFSH [relative ratio (RR): 1.1; 95% confidence interval (CI): 0.92–1.2]. Treatment with electrocautery resulted in a significantly lower need for stimulated cycles to reach a live birth; 53% after electrocautery versus 76% after rFSH (RR: 0.69; 95% CI: 0.55–0.88).The cumulative proportion of women with a second child was 61% after electrocautery versus 46% after immediate rFSH (RR: 1.4; 95% CI: 1.00–1.9). Overall, there were 7 twins out of 134 deliveries (5%) after electrocautery versus 10 twins out of 124 deliveries (8%) in the rFSH group (RR: 0.65; 95% CI: 0.25–1.6). Fifty-four per cent of the women allocated to electrocautery had a regular menstrual cycle 8–12 years after randomization versus 36% in those allocated to rFSH (RR: 1.5; 95% CI: 0.87–2.6). CONCLUSION In women with clomiphene-resistant PCOS, laparoscopic electrocautery of the ovaries is as effective as ovulation induction with FSH treatment in terms of live births, but reduces the need for ovulation induction or ART in a significantly higher proportion of women and increases the chance for a second child. Clinicians may use these data when informing clomiphene-resistant anovulatory women about treatment options.
Keywords: clomiphene citrate; PCOS; electrocautery; ovulation induction; follicle-stimulating hormone
Rights: © The Author 2011. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
RMID: 0020136843
DOI: 10.1093/humrep/der141
Appears in Collections:Obstetrics and Gynaecology publications

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