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https://hdl.handle.net/2440/86734
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Type: | Journal article |
Title: | Interaction of the efflux transporters ABCB1 and ABCG2 with imatinib, nilotinib, and dasatinib |
Author: | Eadie, L. Hughes, T. White, D. |
Citation: | Clinical Pharmacology and Therapeutics, 2014; 95(3):294-306 |
Publisher: | Mosby |
Issue Date: | 2014 |
ISSN: | 0009-9236 1532-6535 |
Statement of Responsibility: | L N Eadie, T P Hughes and D L White |
Abstract: | The efflux transporters adenosine triphosphate (ATP)-binding cassette (ABC)B1 and ABCG2 have been demonstrated to interact with the tyrosine kinase inhibitors (TKIs) imatinib, nilotinib, and dasatinib. However, although some studies conclude that TKIs are substrates of one or both transporters, other studies demonstrate only an inhibitory function. This variation is probably due to differences in the concentration of TKIs assayed and the experimental systems used. This article examines the evidence for clinically relevant interactions between three currently approved TKIs and ABCB1/ABCG2. |
Keywords: | Animals Humans Benzamides Piperazines Pyrimidines Thiazoles ATP-Binding Cassette Transporters Neoplasm Proteins Enzyme Inhibitors Protein-Tyrosine Kinases Imatinib Mesylate Dasatinib ATP Binding Cassette Transporter, Subfamily G, Member 2 ATP Binding Cassette Transporter, Subfamily B ATP Binding Cassette Transporter, Subfamily B, Member 1 |
Rights: | © 2014 American Society for Clinical Pharmacology and Therapeutics |
DOI: | 10.1038/clpt.2013.208 |
Published version: | http://dx.doi.org/10.1038/clpt.2013.208 |
Appears in Collections: | Aurora harvest 2 Medicine publications |
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