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https://hdl.handle.net/2440/87561
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Type: | Journal article |
Title: | Mitomycin-C as adjuvant therapy in the treatment of sebaceous gland carcinoma in high-risk locations |
Author: | Rudkin, A. Muecke, J. |
Citation: | Clinical and Experimental Ophthalmology, 2009; 37(4):352-356 |
Publisher: | Wiley |
Issue Date: | 2009 |
ISSN: | 1442-6404 1442-9071 |
Statement of Responsibility: | Adam K Rudkin and James S Muecke |
Abstract: | Purpose: To report on the use of Mitomycin-C as adjuvant therapy to excision and cryotherapy in patients with sebaceous gland carcinoma (SGC) in high-risk locations. Design: Retrospective, consecutive, case series. Participants: Three patients with SGC of the upper palpebral conjunctiva or caruncle, but without clinical pagetoid spread. Methods: Following excision and double freeze-thaw cryotherapy, patients with histology demonstrating SGC of the ocular surface were treated with topical Mitomycin-C (0.04%). Follow-up was conducted over an average of 30 months (range: 24–37 months). Main outcome measures: Postoperative evidence of local recurrence, lymph node or distant organ metastasis. Results: No patients had evidence of local recurrence or systemic disease. Conclusions: Wide surgical excision with cryotherapy is the basis of treatment of SGC without pagetoid spread. The use of Mitomycin-C as adjuvant therapy remains controversial, although there is some rationale for its use in high-risk situations. |
Keywords: | adjuvant chemotherapy mitomycin recurrence sebaceous gland carcinoma |
Rights: | © 2009 The Authors |
DOI: | 10.1111/j.1442-9071.2009.02048.x |
Published version: | http://dx.doi.org/10.1111/j.1442-9071.2009.02048.x |
Appears in Collections: | Aurora harvest 2 Opthalmology & Visual Sciences publications |
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