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Type: Journal article
Title: Mitomycin-C as adjuvant therapy in the treatment of sebaceous gland carcinoma in high-risk locations
Author: Rudkin, A.
Muecke, J.
Citation: Clinical and Experimental Ophthalmology, 2009; 37(4):352-356
Publisher: Wiley
Issue Date: 2009
ISSN: 1442-6404
Statement of
Adam K Rudkin and James S Muecke
Abstract: Purpose: To report on the use of Mitomycin-C as adjuvant therapy to excision and cryotherapy in patients with sebaceous gland carcinoma (SGC) in high-risk locations. Design: Retrospective, consecutive, case series. Participants: Three patients with SGC of the upper palpebral conjunctiva or caruncle, but without clinical pagetoid spread. Methods: Following excision and double freeze-thaw cryotherapy, patients with histology demonstrating SGC of the ocular surface were treated with topical Mitomycin-C (0.04%). Follow-up was conducted over an average of 30 months (range: 24–37 months). Main outcome measures: Postoperative evidence of local recurrence, lymph node or distant organ metastasis. Results: No patients had evidence of local recurrence or systemic disease. Conclusions: Wide surgical excision with cryotherapy is the basis of treatment of SGC without pagetoid spread. The use of Mitomycin-C as adjuvant therapy remains controversial, although there is some rationale for its use in high-risk situations.
Keywords: adjuvant; chemotherapy; mitomycin; recurrence; sebaceous gland carcinoma
Rights: © 2009 The Authors
RMID: 0030015353
DOI: 10.1111/j.1442-9071.2009.02048.x
Appears in Collections:Opthalmology & Visual Sciences publications

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