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Type: Journal article
Title: Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Author: Speliotes, E.
Palmer, L.
Citation: Nature Genetics, 2010; 42(11):937-948
Publisher: Nature Publishing Group
Issue Date: 2010
ISSN: 1061-4036
Statement of
Elizabeth K Speliotes … Lyle J Palmer … et al.
Abstract: Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
Keywords: MAGIC; Procardis Consortium; Humans; Obesity; Genetic Predisposition to Disease; Body Weight; Body Mass Index; Body Size; Body Height; Chromosome Mapping; Polymorphism, Single Nucleotide; European Continental Ancestry Group; Genome-Wide Association Study
Rights: © 2010 Nature America, Inc. All rights reserved.
RMID: 0020137792
DOI: 10.1038/ng.686
Appears in Collections:Translational Health Science publications

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