Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/8758
Type: Journal article
Title: Maintenance therapy with oral ganciclovir after treatment of cytomegalovirus infection
Author: Nankivell, B.
Malouf, M.
Russ, G.
Barclay, P.
Glanville, A.
Allen, R.
O'Connell, P.
Chapman, J.
Citation: Clinical Transplantation, 1998; 12(3):270-273
Publisher: Blackwell
Issue Date: 1998
ISSN: 0902-0063
1399-0012
Abstract: While oral ganciclovir (OGCV) has been used as primary prophylaxis in patients at high risk for cytomegalovirus (CMV) infection after solid organ transplantation, its value in secondary prophylaxis is unknown. We have examined the use of OGCV as maintenance therapy following confirmed CMV infection on 16 occasions in 15 patients, in kidney (n = 4), kidney pancreas (n = 3) lung (n = 6) and heart lung (n = 1) recipients. OGCV was used in two distinct clinical situations. One group (n = 7) received OGCV as consolidation therapy (mean duration of 21 ± 5 d) following IV ganciclovir induction therapy (mean duration of 16 ± 5 d) for acute CMV infection. and sustained remission was achieved in 6/7 patients for a median follow-up of 300 d. In the second scenario, OGCV suppressed clinical disease in all patients with relapsing CMV infection (n = 9), with minimal or absent toxicity with a median follow-up of 152 d. OGCV reduced morbidity by allowing removal of central lines used for long-term IV therapy in patients with poor peripheral access. Hence, this study demonstrates the safe and effective use of OGCV as consolidation therapy after standard induction treatment with IV ganciclovir, and as long-term suppressive therapy in transplant recipients with recurrent CMV infection.
Keywords: Humans; Cytomegalovirus Infections; Ganciclovir; Antiviral Agents; Organ Transplantation; Administration, Oral; Statistics, Nonparametric; Retrospective Studies; Adult; Female; Male
RMID: 0030005007
Appears in Collections:Medicine publications

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