Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/87656
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Type: Journal article
Title: Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
Author: Chambers, J.
Palmer, L.
Citation: Nature Genetics, 2011; 43(11):1131-1138
Publisher: Nature Publishing Group
Issue Date: 2011
ISSN: 1061-4036
1546-1718
Statement of
Responsibility: 
John C Chambers ... Genetic Investigation of Anthropometric Traits (GIANT) Consortium ... International Consortium for Blood Pressure (ICBP-GWAS), Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC) ... et al.
Abstract: Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10−8 to P = 10−190). We used functional genomic approaches including metabonomic profiling and gene expression analyses to identify probable candidate genes at these regions. We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827). Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function.
Keywords: Liver
Description: L J Palmer is a member of: Genetic Investigation of Anthropometric Traits (GIANT) Consortium; International Consortium for Blood Pressure (ICBP-GWAS); Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC)
Rights: © 2011 Nature America, Inc. All rights reserved.
RMID: 0020137849
DOI: 10.1038/ng.970
Appears in Collections:Translational Health Science publications

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