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Type: Journal article
Title: Practical recommendations for pharmacogenomics-based prescription: 2010 ESF-UB Conference on Pharmacogenetics and Pharmacogenomics
Author: Becquement, L.
Alfirevic, A.
Amstutz, U.
Brauch, H.
Jacqz-Algrain, E.
Laurent-Puig, P.
Molina, M.
Niemi, M.
Schwab, M.
Somogyi, A.
Thervet, E.
Maitland-van der Zee, A.
van Kuilenburg, A.
van Schaik, R.
Verstuyft, C.
Wadelius, M.
Daly, A.
Citation: Pharmacogenomics, 2011; 12(1):113-124
Publisher: Future Medicine
Issue Date: 2011
ISSN: 1462-2416
Statement of
Laurent Becquemont, Ana Alfirevic, Ursula Amstutz, Hiltrud Brauch, Evelyne Jacqz-Aigrain, Pierre Laurent-Puig, Miguel A Molina, Mikko Niemi, Matthias Schwab, Andrew A Somogyi, Eric Thervet, Anke-Hilse Maitland-van der Zee, André BP van Kuilenburg, Ron HN van Schaik, Céline Verstuyft, Mia Wadelius, Ann K Daly
Abstract: The present article summarizes the discussions of the 3rd European Science Foundation-University of Barcelona (ESF-UB) Conference in Biomedicine on Pharmacogenetics and Pharmacogenomics, which was held in June 2010 in Spain. It was focused on practical applications in routine medical practice. We provide practical recommendations for ten different clinical situations, that have either been approved or not approved by regulatory agencies. We propose some comments that might accompany the results of these tests, indicating the best drug and doses to be prescribed. The discussed examples include KRAS, cetuximab, panitumumab, EGFR-gefitinib, CYP2D6-tamoxifen, TPMT-azathioprine-6-mercaptopurine, VKORC1/CYP2C9-warfarin, CYP2C19-clopidogrel, HLA-B*5701-abacavir, HLA-B*5701-flucloxacillin, SLCO1B1-statins and CYP3A5-tacrolimus. We hope that these practical recommendations will help physicians, biologists, scientists and other healthcare professionals to prescribe, perform and interpret these genetic tests.
Keywords: adverse drug reaction; azathioprine; cetuximab; clopidogrel; gefitinib; genetic testing; pharmacogenetics; statins; tacrolimus; tamoxifen; warfarin
Rights: © 2011 Future Medicine Ltd
RMID: 0030015539
DOI: 10.2217/PGS.10.147
Appears in Collections:Pharmacology publications

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