Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/8776
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dc.contributor.authorRusso, A.en
dc.contributor.authorFraser, R.en
dc.contributor.authorHorowitz, M.en
dc.date.issued1996en
dc.identifier.citationDiabetologia, 1996; 39(8):984-989en
dc.identifier.issn0012-186Xen
dc.identifier.issn1432-0428en
dc.identifier.urihttp://hdl.handle.net/2440/8776-
dc.description.abstractThe effects of hyperglycaemia on postprandial small intestinal motor activity are unclear. Duodenal and jejunal pressures and duodeno-caecal transit were measured in eight healthy male volunteers during euglycaemia (blood glucose 4-6 mmol/l) and hyperglycaemia (blood glucose 12-15 mmol/l). Duodenal and jejunal pressures were recorded with a manometric assembly during intraduodenal infusion of 100 ml nutrient liquid comprising 14% protein, 31.5% fat and 54.5% carbohydrate together with 15 glactulose. Duodeno-caecal transit was determined by a breath hydrogen technique. The number of duodenal (p < 0.05) and jejunal (p < 0.01) pressure waves, excluding phase III episodes was reduced during hyperglycaemia compared to euglycaemia Hyperglycaemia was associated with earlier onset of phase III activity (30 +/- 12 vs 132 +/- 20 min; p < 0.05) Duodeno-caecal transit was slower during hyperglycaemia when compared to euglycaemia (114 +/- 17 vs 49 +/- 6 min, p < 0.01). We conclude that induced hyperglycaemia has major effects on postprandial small intestinal motility. The reduction in duodenal and jejunal motor activity is likely to explain the retardation of small intestinal transit during hyperglycaemia.en
dc.language.isoenen
dc.publisherSPRINGER VERLAGen
dc.subjectIntestine, Small; Humans; Hyperglycemia; Acute Disease; Glucose; Blood Glucose; Infusions, Intravenous; Cross-Over Studies; Single-Blind Method; Manometry; Patient Compliance; Gastrointestinal Motility; Pressure; Time Factors; Adult; Maleen
dc.titleThe effect of acute hyperglycaemia on small intestinal motility in normal subjects.en
dc.typeJournal articleen
dc.identifier.rmid0030004996en
dc.identifier.doi10.1007/BF00403919en
dc.identifier.pubid69002-
pubs.library.collectionMedicine publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
Appears in Collections:Medicine publications

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