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Type: Journal article
Title: Markers of sulfadoxine-pyrimethamine-resistant Plasmodium falciparum in placenta and circulation of pregnant women
Author: Mockenhaupt, F.
Bedu-Addo, G.
Junge, C.
Hommerich, L.
Eggelte, T.
Bienzle, U.
Citation: Antimicrobial Agents and Chemotherapy, 2007; 51(1):332-334
Publisher: American Society for Microbiology
Issue Date: 2007
ISSN: 0066-4804
Statement of
Frank P. Mockenhaupt, George Bedu-Addo, Claudia Junge, Lena Hommerich, Teunis A. Eggelte, and Ulrich Bienzle
Abstract: Placental sequestration of Plasmodium falciparum in pregnancy may impair the usefulness of molecular markers of sulfadoxine-pyrimethamine resistance. In 300 infected, delivering women, the concordance of PCR-restriction fragment length polymorphism-derived parasite resistance alleles in matched samples from placenta and circulation was 83 to 98%. Sulfadoxine-pyrimethamine resistance typing in peripheral blood is reasonably representative of P. falciparum infecting pregnant women.
Keywords: Placenta; Animals; Humans; Plasmodium falciparum; Pregnancy Complications, Parasitic; Malaria, Falciparum; Sulfadoxine; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Biological Markers; Drug Combinations; Antimalarials; Polymerase Chain Reaction; Pregnancy; Drug Resistance; Genotype; Mutation; Polymorphism, Restriction Fragment Length; Adolescent; Adult; Middle Aged; Female
Rights: Copyright © 2007, American Society for Microbiology
RMID: 0030013427
DOI: 10.1128/AAC.00856-06
Appears in Collections:Ecology, Evolution and Landscape Science publications

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