Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/8818
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Lack of inhibition of glyceryl trinitrate by diphenyleneiodonium in bovine coronary artery. |
Author: | de la Lande, I. Philp, T. Stafford, I. Horowitz, J. |
Citation: | European Journal of Pharmacology, 1996; 314(3):347-350 |
Publisher: | ELSEVIER SCIENCE BV |
Issue Date: | 1996 |
ISSN: | 0014-2999 1879-0712 |
Abstract: | Recent studies indicate that diphenyleneiodonium is a potent inhibitor of glyceryl trinitrate-induced relaxation in rat aorta precontracted with phenylephrine. We have explored the generality of this action in bovine coronary artery precontracted with the thromboxane A2 mimetic, 9,11-dideoxy-11 alpha, 9 alpha-epoxy-methano-prostaglandin F2 alpha (U46619). Diphenyleneiodonium 0.3 microM was without effect (endothelium absent) or caused mild potentiation (0.3 microM or 10 microM; endothelium present) of the relaxant response to gylceryl trinitrate. Lack of inhibition was not due to U46619, since inhibition was still prominent in rat aorta precontracted with this agent. It is concluded that diphenyleneiodonium distinguishes between cellular mechanisms mediating vasodilator responses to glyceryl trinitrate in rat aorta and bovine coronary artery. |
Keywords: | Aorta, Thoracic Coronary Vessels Animals Cattle Rats Nitroglycerin Onium Compounds Vasodilator Agents Enzyme Inhibitors In Vitro Techniques NADPH Oxidases |
DOI: | 10.1016/S0014-2999(96)00729-7 |
Published version: | http://dx.doi.org/10.1016/s0014-2999(96)00729-7 |
Appears in Collections: | Aurora harvest Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.