Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/88469
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Type: Journal article
Title: Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts
Author: Boraska, V.
Palmer, L.
Citation: PLoS One, 2012; 7(3):e31369-1-e31369-10
Publisher: Public Library of Science
Issue Date: 2012
ISSN: 1932-6203
1932-6203
Statement of
Responsibility: 
Vesna Boraska ... Lyle J. Palmer ... et al.
Abstract: Brachial circumference (BC), also known as upper arm or mid arm circumference, can be used as an indicator of muscle mass and fat tissue, which are distributed differently in men and women. Analysis of anthropometric measures of peripheral fat distribution such as BC could help in understanding the complex pathophysiology behind overweight and obesity. The purpose of this study is to identify genetic variants associated with BC through a large-scale genome-wide association scan (GWAS) meta-analysis. We used fixed-effects meta-analysis to synthesise summary results across 14 GWAS discovery and 4 replication cohorts comprising overall 22,376 individuals (12,031 women and 10,345 men) of European ancestry. Individual analyses were carried out for men, women, and combined across sexes using linear regression and an additive genetic model: adjusted for age and adjusted for age and BMI. We prioritised signals for follow-up in two-stages. We did not detect any signals reaching genome-wide significance. The FTO rs9939609 SNP showed nominal evidence for association (p<0.05) in the age-adjusted strata for men and across both sexes. In this first GWAS meta-analysis for BC to date, we have not identified any genome-wide significant signals and do not observe robust association of previously established obesity loci with BC. Large-scale collaborations will be necessary to achieve higher power to detect loci underlying BC.
Keywords: Arm; Humans; Obesity; Genetic Predisposition to Disease; Proteins; Anthropometry; Body Mass Index; Cohort Studies; Chromosome Mapping; Genotype; Polymorphism, Single Nucleotide; Adolescent; Adult; Aged; Aged, 80 and over; Middle Aged; European Continental Ancestry Group; Female; Male; Overweight; Genome-Wide Association Study; Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Rights: © 2012 Boraska et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
RMID: 0020136613
DOI: 10.1371/journal.pone.0031369
Grant ID: http://purl.org/au-research/grants/nhmrc/572613
http://purl.org/au-research/grants/nhmrc/403981
http://purl.org/au-research/grants/nhmrc/353514
Appears in Collections:Translational Health Science publications

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