Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture|
|Citation:||Nature Genetics, 2013; 45(5):501-512|
|Publisher:||Nature Publishing Group|
|Sonja I Berndt ... Lyle J Palmer ... et al.|
|Abstract:||Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.|
|Keywords:||Humans; Obesity; Genetic Predisposition to Disease; Anthropometry; Body Mass Index; Body Height; Waist-Hip Ratio; Case-Control Studies; Genotype; Phenotype; Polymorphism, Single Nucleotide; Quantitative Trait Loci; European Continental Ancestry Group; Meta-Analysis as Topic; Genome-Wide Association Study|
|Rights:||© 2013 Nature America, Inc. All rights reserved.|
|Appears in Collections:||Translational Health Science publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.