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https://hdl.handle.net/2440/88617
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dc.contributor.author | Taal, H. | - |
dc.contributor.author | St Pourcain, B. | - |
dc.contributor.author | Thiering, E. | - |
dc.contributor.author | Das, S. | - |
dc.contributor.author | Mook-Kanamori, D. | - |
dc.contributor.author | Warrington, N. | - |
dc.contributor.author | Kaakinen, M. | - |
dc.contributor.author | Kreiner-Møller, E. | - |
dc.contributor.author | Bradfield, J. | - |
dc.contributor.author | Freathy, R. | - |
dc.contributor.author | Geller, F. | - |
dc.contributor.author | Guxens, M. | - |
dc.contributor.author | Cousminer, D. | - |
dc.contributor.author | Kerkhof, M. | - |
dc.contributor.author | Timpson, N. | - |
dc.contributor.author | Arfan Ikram, M. | - |
dc.contributor.author | Beilin, L. | - |
dc.contributor.author | Bønnelykke, K. | - |
dc.contributor.author | Buxton, J. | - |
dc.contributor.author | Charoen, P. | - |
dc.contributor.author | et al. | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Nature Genetics, 2012; 44(5):532-538 | - |
dc.identifier.issn | 1061-4036 | - |
dc.identifier.issn | 1546-1718 | - |
dc.identifier.uri | http://hdl.handle.net/2440/88617 | - |
dc.description.abstract | To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 × 10−9) and rs1042725 on chromosome 12q15 (P = 2.8 × 10−10) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height, their effects on infant head circumference were largely independent of height (P = 3.8 × 10−7 for rs7980687 and P = 1.3 × 10−7 for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 × 10−6). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume, Parkinson's disease and other neurodegenerative diseases indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life. | - |
dc.description.statementofresponsibility | H Rob Taal ... The Cohorts for Heart and Aging Research in Genetic Epidemiology (CHARGE) Consortium ... The Early Genetics, Lifecourse Epidemiology (EAGLE) Consortium ... Lyle J Palmer ... et al. for the Early Growth Genetics(EGG) Consortium | - |
dc.language.iso | en | - |
dc.publisher | Nature Publishing Group | - |
dc.rights | © 2012 Nature America, Inc. All rights reserved | - |
dc.source.uri | http://dx.doi.org/10.1038/ng.2238 | - |
dc.subject | Cohorts for Heart and Aging Research in Genetic Epidemiology (CHARGE) Consortium | - |
dc.subject | Early Genetics & Lifecourse Epidemiology (EAGLE) consortium | - |
dc.subject | Early Growth Genetics (EGG) Consortium | - |
dc.subject | Head | - |
dc.subject | Chromosomes, Human, Pair 12 | - |
dc.subject | Humans | - |
dc.subject | Pregnancy Complications | - |
dc.subject | Genetic Markers | - |
dc.subject | Pregnancy | - |
dc.subject | Polymorphism, Single Nucleotide | - |
dc.subject | Infant | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Meta-Analysis as Topic | - |
dc.subject | Genome-Wide Association Study | - |
dc.subject | Genetic Loci | - |
dc.subject | White People | - |
dc.title | Common variants at 12q15 and 12q24 are associated with infant head circumference | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1038/ng.2238 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 2 Translational Health Science publications |
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