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Type: Journal article
Title: Obesity-susceptibility loci have a limited influence on birth weight: A meta-analysis of up to 28,219 individuals
Author: Kilpelainen, T.
den Hoed, M.
Ong, K.
Grontved, A.
Brage, S.
Early Growth Genetics Consortium
Jameson, K.
Cooper, C.
Khaw, K.
Ekeund, U.
Wareham, N.
Loos, R.
Citation: American Journal of Clinical Nutrition, 2011; 93(4):851-860
Publisher: American Society for Clinical Nutrition
Issue Date: 2011
ISSN: 0002-9165
Statement of
Tuomas O Kilpeläïnen, Marcel den Hoed, Ken K Ong, Anders Grøntved, Soren Brage, Early Growth Genetics Consortium, Karen Jameson, Cyrus Cooper, Kay-Tee Khaw, Ulf Ekelund, Nicholas J Wareham, and Ruth JF Loos
Abstract: High birth weight is associated with adult body mass index (BMI). We hypothesized that birth weight and BMI may partly share a common genetic background.The objective was to examine the associations of 12 established BMI variants in or near the NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, BCDIN3D, SH2B1, FTO, MC4R, and KCTD15 genes and their additive score with birth weight.A meta-analysis was conducted with the use of 1) the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk, Hertfordshire, Fenland, and European Youth Heart Study cohorts (n(max) = 14,060); 2) data extracted from the Early Growth Genetics Consortium meta-analysis of 6 genome-wide association studies for birth weight (n(max) = 10,623); and 3) all published data (n(max) = 14,837).Only the MTCH2 and FTO loci showed a nominally significant association with birth weight. The BMI-increasing allele of the MTCH2 variant (rs10838738) was associated with a lower birth weight (β ± SE: -13 ± 5 g/allele; P = 0.012; n = 23,680), and the BMI-increasing allele of the FTO variant (rs1121980) was associated with a higher birth weight (β ± SE: 11 ± 4 g/allele; P = 0.013; n = 28,219). These results were not significant after correction for multiple testing.Obesity-susceptibility loci have a small or no effect on weight at birth. Some evidence of an association was found for the MTCH2 and FTO loci, ie, lower and higher birth weight, respectively. These findings may provide new insights into the underlying mechanisms by which these loci confer an increased risk of obesity.
Keywords: Early Growth Genetics Consortium; Humans; Obesity; Birth Weight; Proteins; Membrane Transport Proteins; Mitochondrial Membrane Transport Proteins; Mitochondrial Proteins; Body Mass Index; Alleles; Adult; Aged; Aged, 80 and over; Middle Aged; Female; Male; Genome-Wide Association Study; Young Adult; Genetic Loci; Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Description: Lyle J. Palmer is a member of the Early Growth Genetics Consortium
Rights: © 2011 American Society for Nutrition
RMID: 0020136626
DOI: 10.3945/ajcn.110.000828
Appears in Collections:Translational Health Science publications

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