Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/8934
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Type: Journal article
Title: Nitrate therapy is an alternative to furosemide/morphine therapy in the management of acute cardiogenic pulmonary edema
Author: Beltrame, J.
Zietz, C.
Unger, S.
Brennan, R.
Hunt, A.
Moran, J.
Horowitz, J.
Citation: Journal of Cardiac Failure, 1998; 4(4):271-279
Issue Date: 1998
ISSN: 1532-8414
1532-8414
Statement of
Responsibility: 
John F. Beltrame, Christopher J. Zeitz, Steven A. Unger, Richard J. Brennan, Allan Hunt, John L. Moran and John D. Horowitz
Abstract: Background: Nitrates are superior to furosemide in the management of acute pulmonary edema associated with myocardial infarction; however, their role in the absence of infarction is unclear. Methods and Results: A randomized comparison was undertaken of the relative effectiveness of primary therapy with either intravenous morphine/furosemide (men/women; n = 32) or nitroglycerin/N-acetylcysteine (NTG/NAC; n = 37) in consecutive patients with acute pulmonary edema. The primary end point was change in Pao2/Fio2 over the first 60 minutes of therapy. Secondary end points were needed for mechanical respiratory assistance (ie, continuous positive airway pressure via mask or intubation and ventilation) and changes in other gas exchange parameters. Both treatment groups showed improvement in oxygenation after 60 minutes of therapy; however, this reached statistical significance only with NTG/ NAC therapy. There was no significant difference between groups in the assessed parameters (95% Cl for differences in Pao2/Fio2: furosemide/morphine −12 to 23 and NTG/NAC 4 to 44), a finding also confirmed in 32 patients presenting with respiratory failure. Only 11% of the study group required mechanical ventilatory assistance (continuous positive airway pressure in 4 patients and intubation and ventilation in 3 patients). Conclusions: NTG/NAC therapy is as effective as furosemide/morphine in the initial management of acute pulmonary edema, regardless of the presence or absence of respiratory failure. The necessity for mechanical ventilatory assistance is infrequent in these patients, regardless of the initial medical treatment regimen.
Keywords: Acute pulmonary edema, acute heart failure, diuretics, nitrate tolerance
Rights: Copyright © 1998 Published by Elsevier Inc.
RMID: 0030004898
DOI: 10.1016/S1071-9164(98)90232-9
Appears in Collections:Medicine publications

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