Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/89425
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Type: Journal article
Title: Drosophila as a model for chromosomal instability
Author: Liu, D.
Shaukat, Z.
Hussain, R.
Khan, M.
Gregory, S.
Citation: AIMS Genetics, 2015; 2(1):1-12
Publisher: AIMS Press
Issue Date: 2015
ISSN: 2377-1143
Statement of
Responsibility: 
Dawei Liu, Zeeshan Shaukat, Rashid Hussain, Mahwish Khan and Stephen L. Gregory
Abstract: Chromosomal instability (CIN) is a common feature of tumours that leads to increased genetic diversity in the tumour and poor clinical outcomes. There is considerable interest in understanding how CIN comes about and how its contribution to drug resistance and metastasis might be counteracted. In the last decade a number of CIN model systems have been developed in Drosophila that offer unique benefits both in understanding the development of CIN in a live animal as well as giving the potential to do genome wide screens for therapeutic candidate genes. This review outlines the mechanisms used in several Drosophila CIN model systems and summarizes some significant outcomes and opportunities that they have produced - See more at: http://www.aimspress.com/aimsg/ch/reader/view_abstract.aspx?file_no=Genetics2014003&flag=1#sthash.Jo65Iimr.dpuf
Keywords: aneuploidy; cell cycle; checkpoint; chromosomal instability; DNA damage; Drosophila; JNK; metabolism; ROS
Rights: ©2015, Stephen L. Gregory, et al., licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
RMID: 0030023512
DOI: 10.3934/genet.2015.1.1
Grant ID: http://purl.org/au-research/grants/nhmrc/1027878
Appears in Collections:Genetics publications

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