Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/9076
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | The DD genotype of the angiotensin-converting enzyme gene occurs in very low frequency in Australian Aboriginals |
Author: | Lester, S. Heatley, S. Bardy, P. Bahnisch, J. Bannister, K. Faull, R. Clarkson, A. |
Citation: | Nephrology Dialysis Transplantation, 1999; 14(4):887-890 |
Publisher: | OXFORD UNIV PRESS |
Issue Date: | 1999 |
ISSN: | 0931-0509 1460-2385 |
Statement of Responsibility: | Susan Lester, Susan Heatley, Peter Bardy, John Bahnisch, Kym Bannister, Randall Faull and Anthony Clarkson |
Abstract: | <h4>Background</h4>The DD genotype of the angiotensin-converting enzyme (ACE) gene appears to be an independent risk factor for myocardial infarction, left ventricular hypertrophy and an increased incidence and rate of progression of renal disease. The high incidence of renal disease and end-stage renal failure in the Australian Aboriginal population has prompted investigation of ACE genotypes in these people.<h4>Methods</h4>ACE genotypes were determined in four groups: (i) normal Australian Caucasian blood donors (n = 100), (ii) Caucasian renal transplant recipients (n = 173), (iii) normal Australian Aboriginals from a single tribe (n = 184), and (iv) Australian Aboriginals included in the renal-transplant programme (n = 94).<h4>Findings</h4>The D allele frequency in the normal Australian Caucasian (54.5%) and renal transplant groups (57.2%) was similar. However, the D allele frequency in the normal Australian Aboriginal (3%) and Aboriginal renal patient group (14.4%) was significantly lower than both Caucasian groups.<h4>Interpretation</h4>The D allele of the ACE gene has little or no influence on the renal disease of Australian Aboriginals. |
Keywords: | ACE genotype Australian Aboriginals renal failure |
DOI: | 10.1093/ndt/14.4.887 |
Published version: | http://dx.doi.org/10.1093/ndt/14.4.887 |
Appears in Collections: | Aurora harvest Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.