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dc.contributor.authorCallen, D.F.en
dc.identifier.citationIn Situ hybridization protocols, 1994 / Choo, K.H.A. (ed./s), Ch.32, pp.439-457en
dc.description.abstractA marker chromosome is one that is morphologically different from any normal chromosome with its origin not being readily discernible by classical cytogenetic techniques. Marker chromosomes in neoplasia often represent the products of complex rearrangements and will not be discussed in this chapter. From a large series of 377,357 karyotyped amniocentesis specimens in a multicenter survey, an unbiased estimate of the frequency of de novo constitutional marker chromosomes was 1 in 2500 (1). The overall population frequency will be higher than this since markers identified as i(18p) or i(12p), and markers that were familial, were excluded. Since the proportion of familial markers is in the vicinity of 40% (2), the actual population frequency of marker chromosomes is about 1 in 1200.en
dc.description.statementofresponsibilityDavid F. Callenen
dc.publisherHumana Pressen
dc.relation.ispartofseriesMethods in Molecular Biology; 33en
dc.rightsCopynght © 1994 Humana Press Inc.en
dc.subjectChromosomes, Human; Ring Chromosomes; Humans; Chromosome Aberrations; Indoles; Distamycins; DNA, Satellite; Genetic Markers; Prenatal Diagnosis; Prognosis; In Situ Hybridization; Karyotyping; Cytogenetics; Pregnancy; Infant, Newborn; Female; Maleen
dc.titleCharacterization of constitutive marker chromosomes in humansen
dc.typeBook chapteren
pubs.library.collectionMedicine publicationsen
dc.identifier.orcidCallen, D.F. [0000-0002-6189-9991]en
Appears in Collections:Medicine publications

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