Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/91450
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Type: Journal article
Title: Tissue oxygenation and red cell 2,3-diphosphoglycerate in normal and abnormal pregnancy
Author: MacLennan, A.
Emerson, P.
Hunter, D.
Darley, J.
Citation: British Journal of Obstetrics and Gynaecology, 1976; 83(5):378-382
Publisher: Blackwell Science
Issue Date: 1976
ISSN: 0306-5456
1471-0528
Statement of
Responsibility: 
A. H. Maclennan, Pauline M. Emerson, D. J. S. Hunter and J. H. Darley
Abstract: Maternal tissue oxygenation was reflected by the level of red cell, 2,3-diphosphoglycerate (DPG) was measured before, during and after normal pregnancy. Following an initial fall at the beginning of pregnancy there was a significant rise in the mean level of DPG during pregnancy with an abrupt fall in the puerperium. The mean red cell DPG level in the third trimester of pregnancies complicated by pre-eclampsia and diabetes was not statistically different from the normal but the mean value of all pregnancies in which the fetus was stillborn or growth retarded was significantly lower (p less than 0-001). The possible mechanism of the changes in normal and abnormal pregnancy is discussed and it is suggested that the measurement of red cell DPG in the third trimester of pregnancy may prove to be a useful parameter of placental oxygenation.
Keywords: Erythrocytes; Humans; Pregnancy Complications; Fetal Death; Pre-Eclampsia; Pregnancy in Diabetics; Diphosphoglyceric Acids; Oxygen Consumption; Pregnancy; Maternal-Fetal Exchange; Female
Description: Article first published online: 23 AUG 2005
Rights: Copyright status unknown
RMID: 0030023608
DOI: 10.1111/j.1471-0528.1976.tb00846.x
Appears in Collections:Obstetrics and Gynaecology publications

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