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https://hdl.handle.net/2440/91638
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Type: | Journal article |
Title: | Low muscle mass and sarcopenia: common and predictive of osteopenia in inflammatory bowel disease |
Author: | Bryant, R. Ooi, S. Schultz, C. Goess, C. Grafton, R. Hughes, J. Lim, A. Bartholomeusz, F. Andrews, J. |
Citation: | Alimentary Pharmacology and Therapeutics, 2015; 41(9):895-906 |
Publisher: | Wiley |
Issue Date: | 2015 |
ISSN: | 0269-2813 1365-2036 |
Statement of Responsibility: | R. V. Bryant, S. Ooi, C. G. Schultz, C. Goess, R. Grafton, J. Hughes, A. Lim, F. D. Bartholomeusz, and J. M. Andrews |
Abstract: | BACKGROUND: Body composition is poorly studied in inflammatory bowel disease (IBD). Sarcopenia describes a loss of muscle mass and strength. AIM: To assess the prevalence of low lean mass (LM), sarcopenia and associated morbidity in an adult IBD cohort. METHODS: Cross-sectional data were gathered on pre-menopausal 18- to 50-year-old patients with IBD. Whole-body dual-energy X-ray absorptiometry, anthropometric assessment and grip strength were performed. Low LM was defined as ≥1 s.d. below the population mean for appendicular skeletal muscle index [ASMI (kg)/height (m)²], and sarcopenia as both ASMI and grip strength ≥1 s.d. below population mean. Multivariate regression analyses were performed. RESULTS: Of 137 participants (median age 31 years, BMI 24.8 kg/m(2) ), 56% were male and 69% had Crohn's disease (CD). Low LM and sarcopenia were observed in 21% and 12% of patients, respectively, and osteopenia/osteoporosis in 38% of patients (mean lumbar spine t-score -0.3 ± s.d. 1.1). Grip strength predicted low LM and sarcopenia better than did body mass index (BMI) (OR 4.8 vs. OR 0.7 for low-LM, P < 0.05 both). Normal BMI was falsely reassuring in 72% and 76% of patients with low ASMI and sarcopenia, respectively. Low LM and sarcopenia (OR = 3.6, P = 0.03; OR = 6.3, P = 0.02; respectively), but not BMI nor fat mass, predicted osteopenia/osteoporosis. CONCLUSIONS: Low lean mass and sarcopenia are common in patients with IBD, and important to recognise as they predict osteopenia/osteoporosis. Grip strength testing should be incorporated into routine clinical practice to detect low lean mass deficits, which may go unrecognised using BMI alone. |
Keywords: | Humans Bone Diseases, Metabolic Osteoporosis Inflammatory Bowel Diseases Crohn Disease Absorptiometry, Photon Anthropometry Body Mass Index Prevalence Cross-Sectional Studies Body Composition Adult Female Male Young Adult Sarcopenia |
Rights: | © 2015 John Wiley & Sons Ltd |
DOI: | 10.1111/apt.13156 |
Grant ID: | NFC |
Published version: | http://dx.doi.org/10.1111/apt.13156 |
Appears in Collections: | Aurora harvest 2 Medicine publications |
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