Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/91987
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Early cerebral oxygen extraction and the risk of death or sonographic brain injury in very preterm infants |
Author: | Balegar, K. Stark, M. Briggs, N. Andersen, C. |
Citation: | Journal of Pediatrics, 2014; 164(3):475-480.e1 |
Publisher: | Mosby |
Issue Date: | 2014 |
ISSN: | 0022-3476 1097-6833 |
Statement of Responsibility: | Kiran Kumar Balegar, Michael J. Stark, Nancy Briggs, and Chad C. Andersen |
Abstract: | OBJECTIVE: To evaluate the relationship between cerebral fractional tissue oxygen extraction (cFTOE), a measure of oxygen delivery-consumption equilibrium, and the risk of early poor outcome in very preterm infants. STUDY DESIGN: Cerebral blood flow, tissue oxygenation index (by near-infrared spectroscopy), and arterial oxygen content were measured, and cerebral oxygen delivery, consumption, and cFTOE were calculated at 3 intervals in the first 72 hours of life in infants ≤ 30 weeks gestational age (GA). A receiver operating characteristic curve was derived with an a priori defined dichotomized outcome of good or poor, defined as death or sonographic brain injury (grade ≥ II intraventricular hemorrhage) by day 7. RESULTS: Seventy-one infants were enrolled, with a mean (SD) GA of 27 (2) weeks. cFTOE demonstrated better discrimination for the study outcome at <24 hours of age than at 48 or 72 hours of age (P = .01). The area under the curve for cFTOE at the initial measurement was no different from that for GA alone (0.87; 95% CI, 0.77-0.95 vs 0.81; 95% CI, 0.69-0.92), but the combined measure of cFTOE and GA had better discrimination (0.96; 95% CI, 0.91-1.0) than either cFTOE (P = .03) or GA (P = .016) alone. A cFTOE of 0.4 had a sensitivity of 82% and specificity of 75% for risk of early poor outcome. CONCLUSION: Elevated cFTOE values are associated with increased risk of early poor outcome in very preterm infants. Its predictive value is further improved with the addition of GA. |
Keywords: | Carotid Artery, Internal Humans Cerebral Hemorrhage Infant, Premature, Diseases Oxygen Spectroscopy, Near-Infrared Echocardiography Ultrasonography, Doppler, Pulsed Oximetry Respiration, Artificial Logistic Models Sensitivity and Specificity ROC Curve Gestational Age Cerebrovascular Circulation Regional Blood Flow Infant, Newborn Infant, Premature |
Rights: | Copyright © 2014 Mosby Inc. All rights reserved. |
DOI: | 10.1016/j.jpeds.2013.10.041 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/565512 |
Published version: | http://dx.doi.org/10.1016/j.jpeds.2013.10.041 |
Appears in Collections: | Aurora harvest 7 Obstetrics and Gynaecology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.