Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/91987
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dc.contributor.author | Balegar, K. | - |
dc.contributor.author | Stark, M. | - |
dc.contributor.author | Briggs, N. | - |
dc.contributor.author | Andersen, C. | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Journal of Pediatrics, 2014; 164(3):475-480.e1 | - |
dc.identifier.issn | 0022-3476 | - |
dc.identifier.issn | 1097-6833 | - |
dc.identifier.uri | http://hdl.handle.net/2440/91987 | - |
dc.description.abstract | OBJECTIVE: To evaluate the relationship between cerebral fractional tissue oxygen extraction (cFTOE), a measure of oxygen delivery-consumption equilibrium, and the risk of early poor outcome in very preterm infants. STUDY DESIGN: Cerebral blood flow, tissue oxygenation index (by near-infrared spectroscopy), and arterial oxygen content were measured, and cerebral oxygen delivery, consumption, and cFTOE were calculated at 3 intervals in the first 72 hours of life in infants ≤ 30 weeks gestational age (GA). A receiver operating characteristic curve was derived with an a priori defined dichotomized outcome of good or poor, defined as death or sonographic brain injury (grade ≥ II intraventricular hemorrhage) by day 7. RESULTS: Seventy-one infants were enrolled, with a mean (SD) GA of 27 (2) weeks. cFTOE demonstrated better discrimination for the study outcome at <24 hours of age than at 48 or 72 hours of age (P = .01). The area under the curve for cFTOE at the initial measurement was no different from that for GA alone (0.87; 95% CI, 0.77-0.95 vs 0.81; 95% CI, 0.69-0.92), but the combined measure of cFTOE and GA had better discrimination (0.96; 95% CI, 0.91-1.0) than either cFTOE (P = .03) or GA (P = .016) alone. A cFTOE of 0.4 had a sensitivity of 82% and specificity of 75% for risk of early poor outcome. CONCLUSION: Elevated cFTOE values are associated with increased risk of early poor outcome in very preterm infants. Its predictive value is further improved with the addition of GA. | - |
dc.description.statementofresponsibility | Kiran Kumar Balegar, Michael J. Stark, Nancy Briggs, and Chad C. Andersen | - |
dc.language.iso | en | - |
dc.publisher | Mosby | - |
dc.rights | Copyright © 2014 Mosby Inc. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.jpeds.2013.10.041 | - |
dc.subject | Carotid Artery, Internal | - |
dc.subject | Humans | - |
dc.subject | Cerebral Hemorrhage | - |
dc.subject | Infant, Premature, Diseases | - |
dc.subject | Oxygen | - |
dc.subject | Spectroscopy, Near-Infrared | - |
dc.subject | Echocardiography | - |
dc.subject | Ultrasonography, Doppler, Pulsed | - |
dc.subject | Oximetry | - |
dc.subject | Respiration, Artificial | - |
dc.subject | Logistic Models | - |
dc.subject | Sensitivity and Specificity | - |
dc.subject | ROC Curve | - |
dc.subject | Gestational Age | - |
dc.subject | Cerebrovascular Circulation | - |
dc.subject | Regional Blood Flow | - |
dc.subject | Infant, Newborn | - |
dc.subject | Infant, Premature | - |
dc.title | Early cerebral oxygen extraction and the risk of death or sonographic brain injury in very preterm infants | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.jpeds.2013.10.041 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/565512 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Stark, M. [0000-0003-1835-8679] | - |
dc.identifier.orcid | Andersen, C. [0000-0002-1364-4986] | - |
Appears in Collections: | Aurora harvest 7 Obstetrics and Gynaecology publications |
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