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https://hdl.handle.net/2440/9198
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dc.contributor.author | Sturm, K. | - |
dc.contributor.author | Parker, B. | - |
dc.contributor.author | Wishart, J. | - |
dc.contributor.author | Feinle-Bisset, C. | - |
dc.contributor.author | Jones, K. | - |
dc.contributor.author | Chapman, I. | - |
dc.contributor.author | Horowitz, M. | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | American Journal of Clinical Nutrition, 2004; 80(3):656-667 | - |
dc.identifier.issn | 0002-9165 | - |
dc.identifier.issn | 1938-3207 | - |
dc.identifier.uri | http://hdl.handle.net/2440/9198 | - |
dc.description.abstract | <h4>Background</h4>Gastric distension reduces food intake, and antral, rather than proximal, gastric distension may be the dominant mechanism in the induction of appetite-related sensations. Healthy aging is associated with reduced appetite.<h4>Objective</h4>We examined the effects of different energy preloads on appetite, plasma cholecystokinin, antral area, and subsequent energy intake in healthy older and young subjects.<h4>Design</h4>On 3 separate days, 12 young and 12 older subjects consumed 400 mL of a drink containing either 0 kcal (water), 250 kcal, or 750 kcal 70 min before a buffet-style meal.<h4>Results</h4>Hunger was less in the older than in the young subjects (P < 0.001). Both nutrient preloads reduced hunger and increased fullness more than did water (P < 0.02), and older subjects were more full than were the young (P < 0.05). Antral area was greater after the nutrient preloads than after water (P = 0.001) and greater in the older than in the young subjects (P = 0.005). In both groups, food intake was suppressed in an energy-dependent manner (P = 0.008). Plasma cholecystokinin was greater in the older than in the young subjects (P = 0.003). Immediately before the meal, hunger (r = -0.59) and energy intake (r = -0.90) were inversely related and fullness (r = 0.66) was directly related to antral area (all: P < 0.001). Antral area, but not plasma cholecystokinin, was a predictor of subsequent energy intake.<h4>Conclusion</h4>In healthy young and older subjects, the suppression of subsequent energy intake by a liquid preload is nutrient dependent and comparable, and both satiation and satiety are related to antral area and (presumably) antral distension. | - |
dc.description.statementofresponsibility | Kerstin Sturm, Barbara Parker, Judith Wishart, Christine Feinle-Bisset, Karen L Jones, Ian Chapman, and Michael Horowitz | - |
dc.language.iso | en | - |
dc.publisher | Amer Soc Clinical Nutrition | - |
dc.rights | Copyright © 2004 American Society for Clinical Nutrition | - |
dc.source.uri | http://www.ajcn.org/cgi/content/abstract/80/3/656 | - |
dc.subject | antral area | - |
dc.subject | energy intake | - |
dc.subject | older subjects | - |
dc.subject | young subjects | - |
dc.subject | cholecystokinin | - |
dc.title | Energy intake and appetite are related to antral area in healthy young and older subjects | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1093/ajcn/80.3.656 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Feinle-Bisset, C. [0000-0001-6848-0125] | - |
dc.identifier.orcid | Jones, K. [0000-0002-1155-5816] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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