Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/92365
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Type: Book chapter
Title: Nutriomes and personalised nutrition for DNA damage prevention, telomere integrity maintenance and cancer growth control
Author: Fenech, M.
Citation: Advances in nutrition and cancer, 2014 / Zappia, V., Panico, S., Russo, G., Budillon, A., Fulvio Della Ragione (ed./s), Ch.24, pp.427-441
Publisher: Springer-Verlag
Publisher Place: Berlin, Germany
Issue Date: 2014
Series/Report no.: Cancer Treatment and Research ; 159
ISBN: 3642380069
9783642380068
Statement of
Responsibility: 
Michael F. Fenech
Abstract: DNA damage at the base sequence and chromosome level is a fundamental cause of developmental and degenerative diseases. Multiple micronutrients and their interactions with the inherited and/or acquired genome determine DNA damage and genomic instability rates. The challenge is to identify for each individual the combination of micronutrients and their doses (i.e. the nutriome) that optimises genome stability, including telomere integrity and functionality and DNA repair. Using nutrient array systems with high-content analysis diagnostics of DNA damage, cell death and cell growth, it is possible to define, on an individual basis, the optimal nutriome for DNA damage prevention and cancer growth control. This knowledge can also be used to improve culture systems for cells used in therapeutics such as stem cells to ensure that they are not genetically aberrant when returned to the body. Furthermore, this information could be used to design dietary patterns that deliver the micronutrient combinations and concentrations required for preventing DNA damage by micronutrient deficiency or excess. Using this approach, new knowledge could be obtained to identify the dietary restrictions and/or supplementations required to control specific cancers, which is particularly important given that reliable validated advice is not yet available for those diagnosed with cancer.
Keywords: Nutriomes; DNA damage; Telomere; Genome stability; Personalised nutrition
Rights: © Springer-Verlag Berlin Heidelberg 2014
RMID: 0030023845
DOI: 10.1007/978-3-642-38007-5_24
Appears in Collections:Medical Sciences publications

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