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dc.contributor.authorMcLellan, A.en
dc.contributor.authorLing, L.en
dc.contributor.authorAzzopardi, S.en
dc.contributor.authorLee, G.en
dc.contributor.authorLee, G.en
dc.contributor.authorKumar, S.en
dc.contributor.authorWong, M.en
dc.contributor.authorWalters, T.en
dc.contributor.authorLee, J.en
dc.contributor.authorLooi, K.en
dc.contributor.authorHalloran, K.en
dc.contributor.authorStiles, M.en
dc.contributor.authorLever, N.en
dc.contributor.authorFynn, S.en
dc.contributor.authorHeck, P.en
dc.contributor.authorSanders, P.en
dc.contributor.authorMorton, J.en
dc.contributor.authorKalman, J.en
dc.contributor.authorKistler, P.en
dc.identifier.citationEuropean Heart Journal, 2015; 36(28):1812-1821en
dc.description.abstractAIMS: Pulmonary vein isolation (PVI) is the cornerstone of catheter ablation of atrial fibrillation (AF). The intervenous ridge (IVR) may be incorporated into ablation strategies to achieve PVI; however, randomized trials are lacking. We performed a randomized multi-centre international study to compare the outcomes of (i) circumferential antral PVI (CPVI) alone (minimal) vs. (ii) CPVI with IVR ablation to achieve individual PVI (maximal). METHODS AND RESULTS: Two hundred and thirty-four patients with paroxysmal AF underwent CPVI and were randomized to a minimal or maximal ablation strategy. The primary outcome of recurrent atrial arrhythmia was assessed with 7-day Holter monitoring at 6 and 12 months. PVI was achieved in all patients. Radiofrequency ablation time was longer in the maximal group (46.6 ± 14.6 vs. 41.5 ± 13.1 min; P < 0.01), with no significant differences in procedural or fluoroscopy times. At mean follow-up of 17 ± 8 months, there was no difference in freedom from AF after a single procedure between a minimal (70%) and maximal ablation strategy (62%; P = 0.25). In the minimal group, ablation was required on the IVR to achieve electrical isolation in 44%, and was associated with a significant reduction in freedom from AF (57%) compared with the minimal group without IVR ablation (80%; P < 0.01). CONCLUSION: There was no statistically significant difference in freedom from AF between a minimal and maximal ablation strategy. Despite attempts to achieve PVI with antral ablation, IVR ablation is commonly required. Patients in whom antral isolation can be achieved without IVR ablation have higher long-term freedom from AF (the Minimax study; ACTRN12610000863033).en
dc.description.statementofresponsibilityAlex J.A. McLellan, Liang-Han Ling, Sonia Azzopardi, Geraldine A. Lee, Geoffrey Lee, Saurabh Kumar, Michael C.G. Wong, Tomos E. Walters, Justin M. Lee, Khang-Li Looi, Karen Halloran, Martin K. Stiles, Nigel A. Lever, Simon P. Fynn, Patrick M. Heck, Prashanthan Sanders, Joseph B. Morton, Jonathan M. Kalman, Peter M. Kistleren
dc.publisherPublished on behalf of the European Society of Cardiologyen
dc.rights© The Author 2015. For permissions please email: journals.permissions@oup.comen
dc.subjectAblation; Atrial fibrillation; Intervenous ridge; Pulmonary vein isolation; Reconnectionen
dc.titleA minimal or maximal ablation strategy to achieve pulmonary vein isolation for paroxysmal atrial fibrillation: a prospective multi-centre randomized controlled trial (the Minimax study)en
dc.typeJournal articleen
pubs.library.collectionMedicine publicationsen
dc.identifier.orcidSanders, P. [0000-0003-3803-8429]en
Appears in Collections:Medicine publications

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