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Type: Journal article
Title: RON is not a prognostic marker for resectable pancreatic cancer
Author: Tactacan, C.
Chang, D.
Cowley, M.
Humphrey, E.
Wu, J.
Gill, A.
Chou, A.
Nones, K.
Grimmond, S.
Sutherland, R.
Biankin, A.
Daly, R.
Australian Pancreratic Genome Initiative
Citation: BMC Cancer, 2012; 12(1):395-1-395-9
Publisher: BioMed Central
Issue Date: 2012
ISSN: 1471-2407
Statement of
Carole M Tactacan, David K Chang, Mark J Cowley, Emily S Humphrey, Jianmin Wu, Anthony J Gill, Angela Chou, Katia Nones, Sean M Grimmond, Robert L Sutherland, Andrew V Biankin, Roger J Daly, and Australian Pancreratic Genome Initiative
Abstract: Background: The receptor tyrosine kinase RON exhibits increased expression during pancreatic cancer progression and promotes migration, invasion and gemcitabine resistance of pancreatic cancer cells in experimental models. However, the prognostic significance of RON expression in pancreatic cancer is unknown. Methods: RON expression was characterized in several large cohorts, including a prospective study, totaling 492 pancreatic cancer patients and relationships with patient outcome and clinico-pathologic variables were assessed. Results: RON expression was associated with outcome in a training set, but this was not recapitulated in the validation set, nor was there any association with therapeutic responsiveness in the validation set or the prospective study. Conclusions: Although RON is implicated in pancreatic cancer progression in experimental models, and may constitute a therapeutic target, RON expression is not associated with prognosis or therapeutic responsiveness in resected pancreatic cancer.
Keywords: Receptor tyrosine kinase; Biomarker; Gemcitabine; Chemotherapy
Rights: © 2012 Tactacan et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
RMID: 0030035712
DOI: 10.1186/1471-2407-12-395
Appears in Collections:Pathology publications

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