Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/95032
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dc.contributor.authorWorthley, D.en
dc.contributor.authorChurchill, M.en
dc.contributor.authorCompton, J.en
dc.contributor.authorTailor, Y.en
dc.contributor.authorRao, M.en
dc.contributor.authorSi, Y.en
dc.contributor.authorLevin, D.en
dc.contributor.authorSchwartz, M.en
dc.contributor.authorUygur, A.en
dc.contributor.authorHayakawa, Y.en
dc.contributor.authorGross, S.en
dc.contributor.authorRenz, B.en
dc.contributor.authorSetlik, W.en
dc.contributor.authorMartinez, A.en
dc.contributor.authorChen, X.en
dc.contributor.authorNizami, S.en
dc.contributor.authorLee, H.en
dc.contributor.authorKang, H.en
dc.contributor.authorCaldwell, J.en
dc.contributor.authorAsfaha, S.en
dc.contributor.authoret al.en
dc.date.issued2015en
dc.identifier.citationCell, 2015; 160(1-2):269-284en
dc.identifier.issn0092-8674en
dc.identifier.issn1097-4172en
dc.identifier.urihttp://hdl.handle.net/2440/95032-
dc.description.abstractThe stem cells that maintain and repair the postnatal skeleton remain undefined. One model suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise to osteoblasts, chondrocytes, marrow stromal cells, and adipocytes, although the existence of these cells has not been proven through fate-mapping experiments. We demonstrate here that expression of the bone morphogenetic protein (BMP) antagonist gremlin 1 defines a population of osteochondroreticular (OCR) stem cells in the bone marrow. OCR stem cells self-renew and generate osteoblasts, chondrocytes, and reticular marrow stromal cells, but not adipocytes. OCR stem cells are concentrated within the metaphysis of long bones not in the perisinusoidal space and are needed for bone development, bone remodeling, and fracture repair. Grem1 expression also identifies intestinal reticular stem cells (iRSCs) that are cells of origin for the periepithelial intestinal mesenchymal sheath. Grem1 expression identifies distinct connective tissue stem cells in both the bone (OCR stem cells) and the intestine (iRSCs).en
dc.description.statementofresponsibilityDaniel L. Worthley … et al.en
dc.language.isoenen
dc.publisherCell Pressen
dc.rights© 2015 Elsevier Inc.en
dc.subjectMice, Inbred C57BL; Intercellular Signaling Peptides and Proteins; Mesenchymal Stromal Cellsen
dc.titleGremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potentialen
dc.typeJournal articleen
dc.identifier.rmid0030020153en
dc.identifier.doi10.1016/j.cell.2014.11.042en
dc.identifier.pubid168705-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS08en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Medicine publications

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