Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Maternal obesity or weight loss around conception impacts hepatic fatty acid metabolism in the offspring|
|Citation:||Obesity, 2014; 22(7):1685-1693|
|Publisher:||North American Association for the Study of Obesity|
|Lisa M. Nicholas, Leewen Rattanatray, Janna L. Morrison, David O. Kleemann, Simon K. Walker, Song Zhang, Severence MacLaughlin and I. Caroline McMillen|
|Abstract:||OBJECTIVE: To determine the impact of maternal obesity or weight loss during the periconceptional period on programming of lipid metabolism in the liver of the offspring. METHODS: An embryo transfer model was used to investigate the effects of exposure to either maternal obesity and/or weight loss before and for 1-week post-conception on the abundance of key molecules regulating hepatic fatty acid oxidation and lipid synthesis in the 4-month-old lamb. RESULTS: Periconceptional maternal obesity resulted in decreased hepatic PPARα, PGC1α and GCN5 abundance and increased hepatic SIRT1 and AMPKα1, AMPKα2 and SREBP1 abundance in the offspring. Maternal weight loss in obese ewes did not ablate all of these effects of maternal obesity on hepatic metabolism in the lamb. Weight loss in normal weight ewes also resulted in decreased hepatic PGC1α and GCN5 and increased AMPKα2 abundance in the offspring. CONCLUSIONS: Exposure of the oocyte/embryo to either maternal obesity or weight loss during the periconceptional period has long term consequences for hepatic lipid metabolism. These findings highlight the sensitivity of the early embryo to maternal nutrition and the need for dietary interventions which maximize metabolic benefits and minimize metabolic costs for the next generation.|
|Description:||Article first published online: 10 APR 2014|
|Rights:||© 2014 The Obesity Society|
|Appears in Collections:||Obstetrics and Gynaecology publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.