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Type: Journal article
Title: Retinal microvascular damage and vasogenic edema produced by Clostridium perfringens type D epsilon toxin in rats
Author: Finnie, J.
Manavis, J.
Casson, R.
Chidlow, G.
Citation: Journal of Veterinary Diagnostic Investigation, 2014; 26(3):470-472
Publisher: SAGE Publications
Issue Date: 2014
ISSN: 1040-6387
Statement of
John W. Finnie, Jim Manavis, Robert J. Casson, Glyn Chidlow
Abstract: When the brain is exposed to large circulating levels of Clostridium perfringens type D epsilon toxin (EXT), microvascular damage with resulting severe, generalized, vasogenic edema seems to be principally responsible for the ensuing acute, and frequently fatal, neurologic disorder. However, although the blood-retinal barrier resembles in many respects the blood-brain barrier, retinal changes in livestock with acute epsilon intoxication have not, to the authors' knowledge, been previously reported. In rats given an acute dose of ETX, retinal microvascular endothelial injury led to widespread vasogenic edema as assessed immunohistochemically by marked plasma albumin extravasation. As laboratory rodents are a good model of the domestic livestock disease produced by ETX, it is probable that the latter sustain some visual deficit when exposed to large doses of this potent neurotoxin.
Keywords: Clostridium perfringens type D epsilon toxin microvascular injury rat retina vasogenic edema
Description: Published online before print April 16, 2014
Rights: © 2014 The Author(s)
RMID: 0030014202
DOI: 10.1177/1040638714530127
Appears in Collections:Pathology publications

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