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Type: Journal article
Title: Prolonged peripheral nerve stimulation induces persistent changes in excitability of human motor cortex
Author: Charlton, C.
Ridding, M.
Thompson, P.
Miles, T.
Citation: Journal of the Neurological Sciences, 2003; 208(1-2):79-85
Publisher: Elsevier Science BV
Issue Date: 2003
ISSN: 0022-510X
Statement of
C. Shona Charlton, Michael C. Ridding, b, Philip D. Thompson and Timothy S. Miles
Abstract: This study sought to determine whether prolonged peripheral nerve stimulation was effective in inducing persistent "plastic" changes in the excitability of the human motor cortex. The amplitude of the electromyographic response evoked in resting intrinsic hand muscles by focal transcranial magnetic stimulation (TMS) was taken as an index of motor cortical excitability. Twelve subjects were stimulated with each of three protocols, one of which was given on each of three separate occasions. The protocols consisted of various schedules of electrical stimulation of the radial and ulnar nerves or the motor point of the first dorsal interosseous muscle (FDI), or stimulation of FDI motor point paired with low-frequency TMS. Amplitudes of TMS-elicited motor evoked potentials (MEPs) were measured before peripheral stimulation and for 2 h after stimulation. The data from one subject were unusable. In every other subject, all three protocols induced a prolonged, significant facilitation of MEPs in at least some of the three intrinsic hand muscles used. In some instances, MEPs were not enlarged and occasionally were significantly depressed. Different protocols based on peripheral afferent stimulation can induce plastic changes in the organisation of the motor cortex that persist for at least 2 h.
Keywords: Wrist; Muscle, Skeletal; Motor Cortex; Peripheral Nerves; Median Nerve; Radial Nerve; Ulnar Nerve; Humans; Electromyography; Analysis of Variance; Electric Stimulation; Evoked Potentials, Motor; Neuronal Plasticity; Magnetics; Time Factors; Adult; Female; Male
Description: Copyright © 2002 Elsevier Science B.V. All rights reserved.
RMID: 0020030736
DOI: 10.1016/S0022-510X(02)00443-4
Appears in Collections:Medicine publications

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