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Type: Journal article
Title: Mammalian genome evolution as a result of epigenetic regulation of transposable elements
Author: Buckley, R.
Adelson, D.
Citation: Biomolecular Concepts, 2014; 5(3):183-194
Publisher: De Gruyter
Issue Date: 2014
ISSN: 1868-5021
Statement of
Reuben M. Buckley and David L. Adelson
Abstract: Transposable elements (TEs) make up a large proportion of mammalian genomes and are a strong evolutionary force capable of rewiring regulatory networks and causing genome rearrangements. Additionally, there are many eukaryotic epigenetic defense mechanisms able to transcriptionally silence TEs. Furthermore, small RNA molecules that target TE DNA sequences often mediate these epigenetic defense mechanisms. As a result, epigenetic marks associated with TE silencing can be reestablished after epigenetic reprogramming - an event during the mammalian life cycle that results in widespread loss of parental epigenetic marks. Furthermore, targeted epigenetic marks associated with TE silencing may have an impact on nearby gene expression. Therefore, TEs may have driven species evolution via their ability to heritably alter the epigenetic regulation of gene expression in mammals.
Keywords: epigenetics; genome evolution; mammals; transposable elements
Rights: Copyright status unknown
RMID: 0030008843
DOI: 10.1515/bmc-2014-0013
Appears in Collections:Molecular and Biomedical Science publications

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