Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/96908
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dc.contributor.authorElks, C.en
dc.contributor.authorPerry, J.en
dc.contributor.authorSulem, P.en
dc.contributor.authorChasman, D.en
dc.contributor.authorFranceschini, N.en
dc.contributor.authorHe, C.en
dc.contributor.authorLunetta, K.en
dc.contributor.authorVisser, J.en
dc.contributor.authorByrne, E.en
dc.contributor.authorCousminer, D.en
dc.contributor.authorGudbjartsson, D.en
dc.contributor.authorEsko, T.en
dc.contributor.authorFeenstra, B.en
dc.contributor.authorHottenga, J.en
dc.contributor.authorKoller, D.en
dc.contributor.authorKutalik, Z.en
dc.contributor.authorLin, P.en
dc.contributor.authorMangino, M.en
dc.contributor.authorMarongiu, M.en
dc.contributor.authorMcArdle, P.en
dc.contributor.authoret al.en
dc.date.issued2010en
dc.identifier.citationNature Genetics, 2010; 42(12):1077-1085en
dc.identifier.issn1061-4036en
dc.identifier.issn1546-1718en
dc.identifier.urihttp://hdl.handle.net/2440/96908-
dc.description.abstractTo identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10−60) and 9q31.2 (P = 2.2 × 10−33), we identified 30 new menarche loci (all P < 5 × 10−8) and found suggestive evidence for a further 10 loci (P < 1.9 × 10−6). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.en
dc.description.statementofresponsibilityCathy E Elks ... The GIANT Consortium ... Lyle J Palmer ... et al.en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.rights© 2010 Nature America, Inc. All rights reserveden
dc.subjectGIANT Consortium; Humans; Obesity; Genetic Predisposition to Disease; Body Size; Body Height; Reproducibility of Results; Aging; Menarche; Inheritance Patterns; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Time Factors; Adolescent; Child; Female; Genome-Wide Association Study; Genetic Loci; DNA Copy Number Variationsen
dc.titleThirty new loci for age at menarche identified by a meta-analysis of genome-wide association studiesen
dc.typeJournal articleen
dc.identifier.rmid0020136631en
dc.identifier.doi10.1038/ng.714en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/241944en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/339462en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/389927en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/389875en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/389891en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/389892en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/389938en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/442915en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/442981en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/496739en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/552485en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/552498en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/619667en
dc.relation.granthttp://purl.org/au-research/grants/arc/A7960034en
dc.relation.granthttp://purl.org/au-research/grants/arc/A79801419en
dc.relation.granthttp://purl.org/au-research/grants/arc/A79906588en
dc.relation.granthttp://purl.org/au-research/grants/arc/DP0212016en
dc.relation.granthttp://purl.org/au-research/grants/arc/DP0343921en
dc.relation.granthttp://purl.org/au-research/grants/arc/DP0770096en
dc.identifier.pubid15524-
pubs.library.collectionPublic Health publicationsen
pubs.library.teamDS08en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidPalmer, L. [0000-0002-1628-3055]en
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