Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/9698
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Type: Journal article
Title: Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival
Author: Guthridge, M.
Stomski, F.
Barry, E.
Winnall, W.
Woodcock, J.
Mc Clure, B.
Dottore, M.
Berndt, M.
Lopez, A.
Citation: Molecular Cell, 2000; 6(1):99-108
Publisher: Cell Press
Issue Date: 2000
ISSN: 1097-2765
1097-4164
Abstract: In the hemopoietic compartment, IL-3, GM-CSF, and IL-5 receptors are major transducers of survival signals; however, the receptor-proximal events that determine this vital function have not been defined. We have found that IL-3 stimulation induces phosphorylation of Ser-585 of beta(c). This promotes the association of phospho-Ser-585 of beta(c) with 14-3-3 and the p85 subunit of PI 3-K. Mutation of Ser-585 specifically impairs the PI 3-K signaling pathway and reduces cell survival in response to IL-3. These results define a distinct IL-3 receptor-mediated survival pathway regulated by site-specific receptor serine phosphorylation and 14-3-3 binding and suggest that this novel mode of signaling may be utilized by disparate transmembrane receptors that have as a common theme the transduction of survival signals.
Keywords: Cell Line; Hematopoietic System; Animals; Mice; Tyrosine 3-Monooxygenase; Cyclic AMP-Dependent Protein Kinases; Serine; 14-3-3 Proteins; Proteins; Interleukin-3; Receptors, Interleukin-3; Mutagenesis, Site-Directed; Signal Transduction; Cell Division; Cell Survival; Binding Sites; Amino Acid Sequence; Phosphorylation; Phosphatidylinositol 3-Kinases
RMID: 0001001598
DOI: 10.1016/S1097-2765(05)00002-X
Appears in Collections:Medicine publications

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