Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/97120
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Type: Journal article
Title: The validity of the variable "NICU admission" as an outcome measure for neonatal morbidity: a retrospective study
Author: Wiegerinck, M.
Danhof, N.
Van Kaam, A.
Tamminga, P.
Mol, B.
Citation: Acta Obstetricia et Gynecologica Scandinavica, 2014; 93(6):603-609
Publisher: Wiley
Issue Date: 2014
ISSN: 0001-6349
1600-0412
Statement of
Responsibility: 
Melanie M.J. Wiegerinck, Nora A. Danhof, Anton H. Van Kaam, Pieter Tamminga and Ben Willem J. Mol
Abstract: OBJECTIVE: To determine whether "neonatal intensive care unit (NICU) admission" is a valid surrogate outcome measure to assess neonatal condition in clinical studies. DESIGN: Retrospective study. SETTING: Tertiary hospital in the Netherlands. POPULATION: Neonates admitted to NICU during a 10-year period. Inclusion was restricted to singletons born beyond 37 weeks of gestation, and admitted to NICU in the first 24 h for delivery-related morbidity. METHODS: Patient characteristics and admission data were compared for four groups based on the line of care during delivery, i.e. home birth (Ia), midwife-led hospital delivery (Ib), secondary care (II), tertiary care (III). MAIN OUTCOME MEASURES: Percentage of neonates/infants that died during NICU admission, diagnosis on admission, treatment received and a Neonatal Therapeutic Intervention Score System (NTISS). RESULTS: We studied 776 newborns (Ia 52, Ib 25, II 160, III 512, 27 unknown). The mortality rate differed significantly (Ia 15%, Ib 12%, II 22%, III 1%, p < 0.01), as did the NTISS morbidity scores at admission [Ia 12.0 (6.0-23.0), Ib 8.5 (6.3-10.0), II 21.0 (15.0-30.0), III 6.0 (4.0-9.0); p < 0.01], diagnosis at admission, received treatment and the duration of admission. CONCLUSIONS: The severity of neonatal illness after 37 weeks of gestation differed depending on the line of care in which they were born, with neonates born in secondary care consistently having the highest morbidity, and those born in tertiary care having the lowest. NICU admission should not be used as an outcome measure for neonatal morbidity, specifically not when comparing different birth settings.
Keywords: Neonatal morbidity; neonatal intensive care unit; validation; outcome measure; birth setting
Description: Article first published online: 25 APR 2014
Rights: © 2014 Nordic Federation of Societies of Obstetrics and Gynecology
RMID: 0030017792
DOI: 10.1111/aogs.12384
Appears in Collections:Obstetrics and Gynaecology publications

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