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https://hdl.handle.net/2440/97295
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Type: | Journal article |
Title: | Interaction of terbinafine (anti-fungal agent) with perhexiline: a case report |
Author: | Sheikh, A.R. Westley, I. Sallustio, B. Horowitz, J.D. Beltrame, J.F. |
Citation: | Heart Lung and Circulation, 2014; 23(6):e149-e151 |
Publisher: | Elsevier |
Issue Date: | 2014 |
ISSN: | 1443-9506 1444-2892 |
Statement of Responsibility: | Abdul Rauf Sheikh, Ian Westley, Benedetta Sallustio, John D Horowitz, John F Beltrame |
Abstract: | Perhexiline is a unique anti-anginal agent that is frequently used in the treatment of chronic refractory angina. Its utility has been limited because of its complex pharmacokinetics that were only appreciated following the development of a therapeutic perhexiline assay. Perhexiline is cleared primarily via formation of mono-hydroxy metabolites (OH-perhexiline) by cytochrome P450 2D6 (CYP2D6). Drugs that are inhibitors of CYP2D6 may therefore inhibit perhexiline metabolism, increase plasma perhexiline concentration and may consequently increase the risk of toxicity. We report a case of a rise in perhexiline plasma concentration to a toxic level following the introduction of terbinafine hydrochloride; a moderate CYP2D6 inhibiting drug. |
Keywords: | Perhexiline Terbinafine Cytochrome P450 2D6 (CYP2D6) Selective serotonin re-uptake inhibitors (SSRIs) |
Rights: | Crown Copyright © 2013 |
DOI: | 10.1016/j.hlc.2013.11.012 |
Published version: | http://dx.doi.org/10.1016/j.hlc.2013.11.012 |
Appears in Collections: | Aurora harvest 7 Medicine publications |
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